Siebert Justin R, Conta Steencken Amanda, Osterhout Donna J
Lake Erie College of Osteopathic Medicine at Seton Hill, 20 Seton Hill Drive, Greensburg, PA 15601, USA.
Department of Cell and Developmental Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Biomed Res Int. 2014;2014:845323. doi: 10.1155/2014/845323. Epub 2014 Sep 18.
Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas. However, these CSPG deposits form a substantial barrier to regeneration and are largely responsible for the inability to repair damage in the brain and spinal cord. This review discusses the role of CSPGs as inhibitors, the role of inflammation in stimulating CSPG expression near site of injury, and therapeutic strategies for overcoming the inhibitory effects of CSPGs and creating an environment conducive to nerve regeneration.
硫酸软骨素蛋白聚糖（CSPGs）在正常中枢神经系统中广泛表达，在发育过程中作为引导信号，并调节成体中的突触连接。在损伤或疾病状态下，通常会在损伤区域附近观察到CSPG表达增加。然而，这些CSPG沉积物形成了再生的实质性障碍，并且在很大程度上导致了脑和脊髓损伤无法修复。本文综述了CSPGs作为抑制剂的作用、炎症在损伤部位附近刺激CSPG表达中的作用，以及克服CSPGs的抑制作用并创造有利于神经再生环境的治疗策略。
