Ihler Friedrich, Pelz Sabrina, Coors Melanie, Matthias Christoph, Canis Martin
* Department of Otorhinolaryngology, University Medical Center Göttingen , Germany.
Int J Audiol. 2014 Nov;53(11):810-6. doi: 10.3109/14992027.2014.938369.
Cochlear implantation trauma causes both macroscopic and inflammatory trauma. The aim of the present study was to evaluate the effectiveness of the TNF-alpha inhibitor etanercept applied after cochlear implantation trauma on the preservation of acoustic hearing.
Guinea pigs were randomly assigned to three groups receiving cochlear implantation trauma by cochleostomy. In one group, the site was sealed by bone cement with no further treatment. A second group was additionally implanted with an osmotic minipump delivering artificial perilymph into the scala tympani for seven days. In the third group, etanercept 1 mg/ml was added to artificial perilymph. Hearing was assessed by auditory brainstem responses at 2, 4, 6, and 8 kHz prior to and after surgery and on days 3, 5, 7, 14, 28.
Fifteen healthy guinea pigs.
The trauma led to threshold shifts from 50.3 dB ± 16.3 dB to 68.0 dB ± 19.3 dB. Hearing thresholds were significantly lower in etanercept-treated animals compared to controls on day 28 at 8 kHz and from day 3 onwards at 4 and 2 kHz (p < 0.01; two-way RM ANOVA / Bonferroni t-test).
The application of etanercept led to preservation of acoustic hearing after cochlear implantation trauma.
人工耳蜗植入创伤会导致宏观创伤和炎症性创伤。本研究的目的是评估在人工耳蜗植入创伤后应用肿瘤坏死因子-α抑制剂依那西普对保留听觉的有效性。
将豚鼠随机分为三组，通过蜗窗造口术造成人工耳蜗植入创伤。一组用骨水泥封闭手术部位，不进行进一步治疗。第二组额外植入一个渗透微型泵，向鼓阶内输送人工外淋巴液，持续7天。第三组在人工外淋巴液中加入1 mg/ml的依那西普。在手术前后以及术后第3、5、7、14、28天，通过听性脑干反应评估2、4、6和8 kHz频率的听力。
15只健康豚鼠。
创伤导致阈值从50.3 dB±16.3 dB升高到68.0 dB±19.3 dB。在第28天8 kHz频率以及从第3天起4和2 kHz频率时，依那西普治疗的动物听力阈值显著低于对照组（p<0.01；双向重复测量方差分析/邦费罗尼t检验）。
依那西普的应用可在人工耳蜗植入创伤后保留听觉。
