Kaufmann S H
Institut für Medizinische Mikrobiologie und Immunologie, Universität Ulm.
Immun Infekt. 1989 Oct;17(5):169-74.
The relevance of the granuloma to protection against intracellular pathogens has been recognized for a long time. More recently, it has become clear that the cell interactions which take place in a granuloma are highly complex. It appears that not only activation of antibacterial function in infected macrophages by helper T cells, but also lysis of infected host cells is of importance and that a coordinated interplay between different populations of T cells and mononuclear phagocytes is required for effective host resistance.
肉芽肿对抵御细胞内病原体的相关性早已得到认可。最近，人们清楚地认识到，肉芽肿内发生的细胞间相互作用极为复杂。似乎不仅辅助性T细胞激活受感染巨噬细胞的抗菌功能很重要，而且受感染宿主细胞的裂解也很重要，并且不同群体的T细胞和单核吞噬细胞之间需要协同相互作用才能实现有效的宿主抵抗力。
