Department of Emergency, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310000, PR China; Department of Emergency, The Third People's Hospital of Hangzhou, 38 West Lake Avenue, Hangzhou 310000, PR China.
Department of Emergency, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310000, PR China.
Clin Chim Acta. 2015 Jan 15;439:102-6. doi: 10.1016/j.cca.2014.10.010. Epub 2014 Oct 12.
Plasma pituitary adenylate cyclase activating polypeptide (PACAP) concentrations are elevated after traumatic brain injury. We assessed the prognostic value of PACAP for short-term and long-term mortality of acute intracerebral hemorrhage (ICH) patients.
A total of 150 patients and 150 age- and gender- matched healthy controls were recruited. The plasma PACAP concentrations were measured using sandwich immunoassays. ICH severity was assessed using hematoma volume and National Institutes of Health Stroke Scale (NIHSS) score. The end points included 1-week mortality and 6-month mortality. The relationships between plasma PACAP concentrations and ICH severity and the end points were analyzed statistically.
Plasma PACAP concentrations were statistically significantly higher in the ICH patients than in the healthy controls and were correlated positively with hematoma volumes and NIHSS scores using a multivariate linear regression. Multivariate analysis results indicated that plasma PACAP concentration was an independent predictor of 1-week mortality, 6-month mortality and 6-month overall survival. It also had high predictive value based on receiver operating characteristic curve.
Plasma PACAP concentrations are increased and are highly associated with the severity of ICH; PACAP may be a good predictor of short-term and long-term mortality of ICH.
创伤性脑损伤后，血浆垂体腺苷酸环化酶激活肽（PACAP）浓度升高。我们评估了 PACAP 对急性脑出血（ICH）患者短期和长期死亡率的预后价值。
共招募了 150 名患者和 150 名年龄和性别匹配的健康对照者。使用夹心免疫测定法测量血浆 PACAP 浓度。使用血肿量和美国国立卫生研究院卒中量表（NIHSS）评分评估 ICH 严重程度。终点包括 1 周死亡率和 6 个月死亡率。统计分析了血浆 PACAP 浓度与 ICH 严重程度和终点之间的关系。
ICH 患者的血浆 PACAP 浓度明显高于健康对照组，且与血肿量和 NIHSS 评分呈正相关，这与多元线性回归分析结果一致。多变量分析结果表明，血浆 PACAP 浓度是 1 周死亡率、6 个月死亡率和 6 个月总生存率的独立预测因子。基于受试者工作特征曲线，它也具有较高的预测价值。
血浆 PACAP 浓度升高，与 ICH 的严重程度高度相关；PACAP 可能是 ICH 短期和长期死亡率的良好预测指标。
