Lassance-Soares Roberta M, Sood Subeena, Chakraborty Nabarun, Jhamnani Sunny, Aghili Nima, Nashin Hajra, Hammamieh Rasha, Jett Marti, Epstein Stephen E, Burnett Mary Susan
MedStar Cardiovascular Research Network, MedStar Heart Institute, Washington Hospital Center, 108 Irving Street, NW Room 214, Washington, DC, 20010, USA.
J Cardiovasc Transl Res. 2014 Nov;7(8):749-55. doi: 10.1007/s12265-014-9592-2. Epub 2014 Oct 15.
Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor's cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.
慢性应激与心血管疾病风险增加有关。衰老也与血管功能障碍有关。我们假设慢性应激会加速老年小鼠的侧支循环功能障碍。将小鼠分为慢性社会挫败（CSD）组或慢性冷应激（CCS）组。CSD组小鼠被安置在攻击者笼子内的一个盒子里，并暴露于攻击者面前。CCS组小鼠被置于冰水中。慢性应激后，对小鼠进行股动脉结扎（FAL）并测量血流恢复情况。对于CSD组，进行足部外观和使用评分以及行为测试。CSD损害了FAL后的侧支血流恢复。此外，应激小鼠有更严重的缺血损伤、足部功能受损和行为改变。CCS组小鼠也表现出侧支血流恢复受损。慢性应激会导致老年小鼠后肢侧支循环功能障碍，两种应激产生相似变化这一事实强化了这一结论。
