Department of Pathology, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju, 501-757, Korea,
Cancer Metastasis Rev. 2014 Dec;33(4):981-91. doi: 10.1007/s10555-014-9523-3.
Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis for a few decades. Metastasis-associated protein (MTA) family is a group of ubiquitously expressed coregulators, which influences on tumor invasiveness or metastasis. MTA1 has been investigated in various cancers including osteosarcoma, and its overexpression is associated with high-risk features of cancers. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1.
骨肉瘤是儿童中最常见的恶性骨肿瘤，其特征为具有侵袭性的生物学行为和向肺部转移的倾向。治疗模式的改变带来了生存获益；然而，几十年来，在诊断时就已经有转移灶的患者的 5 年生存率仍然较低。转移相关蛋白（MTA）家族是一组广泛表达的核心调节剂，其影响肿瘤的侵袭性或转移。MTA1 已在多种癌症中进行了研究，包括骨肉瘤，其过表达与癌症的高危特征有关。在这篇综述中，我们描述了骨肉瘤的各种分子研究，特别是与 MTA1 相关的研究。
