Vohra Fahim, Al-Kheraif Abdulaziz A, Qadri Talat, Hassan Mohamed Ibrahim Abu, Ahmed Asma, Warnakulasuriya Saman, Javed Fawad
Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh 11541, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2015 Mar;12(1):150-9. doi: 10.1016/j.pdpdt.2014.10.001. Epub 2014 Oct 12.
The aim was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral premalignant lesions.
The addressed focused question was "Is PDT effective in the management of oral premalignant lesions?" PubMed/Medline, Google-Scholar, EMBASE and ISI Web of Knowledge databases were searched from 1984 till June 2014 using different combinations of the following keywords: photodynamic therapy; oral premalignant lesions; leukoplakia; erythroplakia; erythro-leukoplakia; verrucous hyperplasia; and submucous fibrosis. Review articles, experimental studies, case-reports, commentaries, letters to the Editor, unpublished articles and articles published in languages other than English were not sought. The pattern of the present study was customized to mainly summarize the relevant information.
Thirteen studies were included. In these studies, the number of patients ranged between 5 patients and 147 individuals with mean ages ranging between 51 years and 62.2 years. Oral premalignant lesions, which were investigated were leukoplakia, erythroplakia, erythro-leukoplakia and verrucous hyperplasia. Reported number of premalignant lesions ranged between 5 and 225. Laser wavelength, duration of irradiation and power density were 585-660nm, 60s to 16.6min and 100-150mW/cm(2), respectively. Aminolevulinic acid, chlorine-e6, meta-tetrahydroxyphenylchlorin and photofrin were used as photosensitizer. The frequency of PDT application ranged between once and 12 times. Complete, partial and no response to PDT was shown by 27-100%, 5-50% and 0-25% of pre-malignant lesions, respectively. The recurrence rate of pre-malignant lesions was up to 36%.
PDT is effective in the overall management of oral premalignant lesions.
旨在系统评价光动力疗法（PDT）在口腔癌前病变治疗中的疗效。
所关注的核心问题是“PDT在口腔癌前病变治疗中是否有效？”。使用以下关键词的不同组合，在1984年至2014年6月期间对PubMed/Medline、谷歌学术、EMBASE和ISI科学网数据库进行检索：光动力疗法；口腔癌前病变；白斑；红斑；红白斑；疣状增生；以及黏膜下纤维化。未检索综述文章、实验研究、病例报告、评论、致编辑的信、未发表文章以及非英文发表的文章。本研究模式经定制以主要总结相关信息。
纳入13项研究。在这些研究中，患者数量在5例至147例之间，平均年龄在51岁至62.2岁之间。所研究的口腔癌前病变为白斑、红斑、红白斑和疣状增生。报告的癌前病变数量在5个至225个之间。激光波长、照射持续时间和功率密度分别为585 - 660nm、60秒至16.6分钟和100 - 150mW/cm²。氨基乙酰丙酸、氯e6、间四羟基苯基氯卟啉和光卟啉用作光敏剂。PDT应用频率在1次至12次之间。癌前病变对PDT的完全缓解、部分缓解和无反应率分别为27% - 100%、5% - 50%和0% - 25%。癌前病变的复发率高达36%。
PDT在口腔癌前病变的整体治疗中有效。
