Azizullah Azizullah, Rehman Zia Ur, Ali Imran, Murad Waheed, Muhammad Noor, Ullah Waheed, Häder Donat-Peter
Department of Botany, Kohat University of Sciences and Technology (KUST), Kohat, Khyber Pakhtunkhwa, 26000, Pakistan,
Parasitol Res. 2014 Dec;113(12):4321-6. doi: 10.1007/s00436-014-4175-3. Epub 2014 Oct 15.
Dengue, a mosquito-borne viral infection, is one of the major public health concerns in the tropical and subtropical regions of the world. Approximately, 2.5 billion people across the world are at risk from dengue and 50 to 100 million new infections of dengue occur annually. There is yet no vaccine or medicine available against dengue, and treatment remains only supportive. Targeting its vector by a combination of biological and chemical approaches and management of breeding sites are currently the only existing approaches to control or eliminate dengue. Chlorophyll derivatives like chlorophyllin and pheophorbide have been reported as effective natural photosensitizers against larvae of several insects including flies. Chlorophyll derivatives were also reported effective against larval stages of freshwater snails as well as against certain parasites of fish. This article briefly discusses the possible application of chlorophyll derivatives in controlling dengue vectors and hence the disease itself. Chlorophyll derivatives can prove to be a good contributor in an integrated approach against dengue.
登革热是一种由蚊子传播的病毒感染，是世界热带和亚热带地区主要的公共卫生问题之一。全世界约有25亿人面临登革热风险，每年有5000万至1亿新增登革热感染病例。目前尚无针对登革热的疫苗或药物，治疗仍仅为支持性治疗。通过生物和化学方法相结合来靶向其病媒以及管理滋生地，是目前控制或消除登革热的唯一现有方法。叶绿素衍生物如叶绿酸和脱镁叶绿酸已被报道为对包括苍蝇在内的几种昆虫幼虫有效的天然光敏剂。叶绿素衍生物也被报道对淡水蜗牛的幼虫阶段以及某些鱼类寄生虫有效。本文简要讨论了叶绿素衍生物在控制登革热媒介以及因此控制疾病本身方面的可能应用。叶绿素衍生物在对抗登革热的综合方法中可能会是一个很好的贡献因素。
