School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China.
J Photochem Photobiol B. 2010 Jan 21;98(1):52-6. doi: 10.1016/j.jphotobiol.2009.11.003. Epub 2009 Nov 10.
A series of tetraethynylsilanes (TETS) have been synthesized by reaction of silicon tetrachloride (SiCl(4)) with Ar-C triple bond CLi, which was prepared in situ by treatment of Ar-C triple bond CH with n-BuLi. For these TETS thus prepared, their photoactivated insecticidal activities against the 4th-instar larvae of Aedes albopictus (Skuse) were evaluated to enrich the structure-activity relationship. In particular, compound 8 exhibited excellent photoactivated insecticidal activity, the LC(50) value was 0.1346 mg L(-1) under UV light treatment and the irradiation-generated enhancement in the activity was more than 69.58-fold, thus could be exploitable as ideal analog candidates in the search for new photoactivated insecticide leads.
一系列的四乙炔基硅烷（TETS）通过四氯化硅（SiCl(4)）与 Ar-C 三键 CLi 的反应合成，Ar-C 三键 CLi 是通过 Ar-C 三键 CH 与正丁基锂反应原位制备的。对于这些合成的 TETS，评估了它们对 Aedes albopictus（Skuse）四龄幼虫的光激活杀虫活性，以丰富结构-活性关系。特别是，化合物 8 表现出优异的光激活杀虫活性，在 UV 光处理下的 LC(50)值为 0.1346mgL(-1)，活性的辐照增强超过 69.58 倍，因此可作为寻找新型光激活杀虫剂先导的理想模拟候选物。
