Mbaeyi Chukwuma, Kamadjeu Raoul, Mahamud Abdirahman, Webeck Jenna, Ehrhardt Derek, Mulugeta Abraham
Centers for Disease Control and Prevention, Atlanta, Georgia.
Centers for Disease Control and Prevention, Atlanta, Georgia World Health Organization, Somalia Liaison Office, Nairobi, Kenya.
J Infect Dis. 2014 Nov 1;210 Suppl 1(0 1):S173-80. doi: 10.1093/infdis/jit808.
Since the 1988 resolution of the World Health Assembly to eradicate polio, significant progress has been made toward achieving this goal, with the result that only Afghanistan, Nigeria, and Pakistan have never successfully interrupted endemic transmission of wild poliovirus. However, one of the greatest challenges of the Global Polio Eradication Initiative has been that of maintaining the polio-free status of countries in unstable regions with weak healthcare infrastructure, a challenge exemplified by Somalia, a country in the Horn of Africa region. Somalia interrupted indigenous transmission of wild poliovirus in 2002, 4 years after the country established its national polio eradication program. But political instability and protracted armed conflict, with significant disruption of the healthcare system, have left Somalia vulnerable to 2 imported outbreaks of wild poliovirus. The first occurred during 2005-2007, resulting in >200 cases of paralytic polio, whereas the second, which began in 2013, is currently ongoing. Despite immense challenges, the country has a sensitive surveillance system that has facilitated prompt detection of outbreaks, but its weak routine immunization system means that supplementary immunization activities constitute the primary strategy for reaching children with polio vaccines. Conducting vaccination campaigns in a setting of conflict has been at times hazardous, but the country's polio program has demonstrated resilience in overcoming many obstacles to ensure that children receive lifesaving polio vaccines. Regaining and maintaining Somalia's polio-free status will depend on finding innovative and lasting solutions to the challenge of administering vaccines in a setting of ongoing conflict and instability.
自1988年世界卫生大会通过根除脊髓灰质炎的决议以来,在实现这一目标方面已取得重大进展,结果只有阿富汗、尼日利亚和巴基斯坦从未成功阻断野生脊髓灰质炎病毒的地方性传播。然而,全球根除脊髓灰质炎行动面临的最大挑战之一,是在医疗基础设施薄弱的不稳定地区维持国家无脊髓灰质炎状态,索马里这个非洲之角地区的国家就是这一挑战的典型例子。索马里在建立国家根除脊髓灰质炎计划4年后,于2002年阻断了野生脊髓灰质炎病毒的本土传播。但政治不稳定和长期武装冲突,以及医疗系统的严重混乱,使索马里容易受到两次野生脊髓灰质炎病毒输入性疫情的影响。第一次发生在2005 - 2007年期间,导致200多例麻痹性脊髓灰质炎病例,而第二次始于2013年,目前仍在持续。尽管面临巨大挑战,但该国拥有一个敏感的监测系统,有助于及时发现疫情,但其薄弱的常规免疫系统意味着补充免疫活动是为儿童接种脊髓灰质炎疫苗的主要策略。在冲突环境中开展疫苗接种运动有时具有危险性,但该国的脊髓灰质炎计划已展现出韧性,克服了许多障碍,以确保儿童能够接种挽救生命的脊髓灰质炎疫苗。恢复并维持索马里的无脊髓灰质炎状态将取决于找到创新且持久的解决方案,以应对在持续冲突和不稳定环境中进行疫苗接种的挑战。