双相障碍患者未受影响的兄弟姐妹的神经认知功能：与双相患者和健康对照的比较。
Neuro-cognitive functioning in unaffected siblings of patients with bipolar disorder: Comparison with bipolar patients and healthy controls.
机构信息
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Indian J Psychiatry. 2014 Jul;56(3):283-8. doi: 10.4103/0019-5545.140645.
AIM
Neurocognitive tests can provide reliable endophenotypes for bipolar disorder (BD). The aim of this study was to compare the neurocognitive functioning of unaffected siblings of patients of bipolar affective disorder (BPAD) with that of patients with BD and a group of healthy controls.
MATERIALS AND METHODS
A total of 20 unaffected siblings of patients with BD-I, 20 patients of BD-I who were currently in remission and a group of 20 healthy control subjects were assessed for neurocognitive functions using Wisconsin Card Sorting Test, Brief Visuospatial Memory Test-Revised, Hopkins Verbal Learning Test-Revised and Wechsler Adult Intelligence Scale Digit Symbol Test.
RESULTS
Compared to healthy controls, unaffected siblings of patients with BD performed poorly on tests of verbal learning, but no significant differences were seen between the two groups for executive functions, visual learning and psychomotor speed, concentration and graphomotor abilities. Compared to unaffected siblings, patients with BD performed poorly on the tests of executive functions, visual memory, verbal memory, psychomotor speed, concentration, and graphomotor abilities.
CONCLUSION
Verbal memory can serve as an endophenotype of bipolar disorder.
目的
神经认知测试可为双相情感障碍（BD）提供可靠的内表型。本研究旨在比较双相情感障碍（BPAD）患者未受影响的兄弟姐妹与 BD 患者和一组健康对照组的神经认知功能。
材料与方法
使用威斯康星卡片分类测试、简短视觉空间记忆测试修订版、霍普金斯言语学习测试修订版和韦氏成人智力量表数字符号测试对 20 名未受影响的 BD-I 患者的兄弟姐妹、20 名目前缓解期的 BD-I 患者和 20 名健康对照组进行神经认知功能评估。
结果
与健康对照组相比，BD 患者未受影响的兄弟姐妹在言语学习测试中表现不佳，但两组在执行功能、视觉学习和心理运动速度、注意力和手眼协调能力方面无显著差异。与未受影响的兄弟姐妹相比，BD 患者在执行功能、视觉记忆、言语记忆、心理运动速度、注意力和手眼协调能力测试中表现不佳。
结论
言语记忆可作为双相情感障碍的内表型。
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