Hu Zhizhong, Hu Maorong, Yuan Xin, Yu Huijuan, Zou Jingzhi, Zhang Yanyan, Lu Zihang
Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China; School of Public and Administration, Nanchang University, Nanchang, Jiangxi Province 330031, China.
Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, China; School of Public and Administration, Nanchang University, Nanchang, Jiangxi Province 330031, China.
Acta Psychol (Amst). 2022 Jun;226:103563. doi: 10.1016/j.actpsy.2022.103563. Epub 2022 Mar 18.
Bipolar II depression (BD-II) is a subtype of bipolar disorder with recurrent depressive, manic, and frequent depressive episodes as the main clinical manifestations. This study aimed to compare the cognitive function of patients with BD-II with those of healthy siblings and controls to explore the internal phenotype of BD-II in the field of cognitive function.
66 BD-II patients, 58 healthy siblings, and 55 healthy controls were assessed with the Trail Making Test (TMT), Digit Symbol Coding Test (DSCT), Category Fluency, Hopkins Verbal Learning Test-Revised (HVLTR), Brief Visuospatial Memory Test-Revised (BVMT-R), Wechsler Memory Scale 3rd ed. Spatial Span Subtest (WMS-III SS), Neuropsychological Assessment Battery Mazes (NABM), Continuous Performance Test, and Identical Pairs (CPT-IP).
Patients with BD-II showed cognitive deficits in visual learning, reasoning and problem solving, verbal learning, attention/vigilance, working memory, and speed of processing. Healthy siblings showed cognitive deficits in reasoning and problem solving, verbal learning, attention/vigilance, working memory, and speed of processing. Substantial differences were observed among the three groups in reasoning and problem solving.
Verbal learning, working memory, and attention/vigilance may be potential endophenotypes that can be used to identify BD-II among Han Chinese in the early stage.
双相II型抑郁症（BD-II）是双相情感障碍的一种亚型，以反复出现的抑郁、躁狂以及频繁的抑郁发作为主要临床表现。本研究旨在比较BD-II患者与健康同胞及对照组的认知功能，以探索BD-II在认知功能领域的内在表型。
对66例BD-II患者、58名健康同胞和55名健康对照者进行了连线测验（TMT）、数字符号编码测验（DSCT）、类别流畅性测验、修订版霍普金斯词语学习测验（HVLTR）、修订版简短视觉空间记忆测验（BVMT-R）、韦氏记忆量表第三版空间广度分测验（WMS-III SS）、神经心理评估量表迷宫测验（NABM）、持续性操作测验和成对相同刺激测验（CPT-IP）。
BD-II患者在视觉学习、推理与问题解决、言语学习、注意力/警觉性、工作记忆和加工速度方面存在认知缺陷。健康同胞在推理与问题解决、言语学习、注意力/警觉性、工作记忆和加工速度方面存在认知缺陷。三组在推理与问题解决方面存在显著差异。
言语学习、工作记忆和注意力/警觉性可能是潜在的内表型，可用于早期识别汉族人群中的BD-II。
