Alakuijala Anniina, Maasilta Paula, Bachour Adel
Department of Clinical Neurophysiology, HUS Medical Imaging Center, Helsinki University Central Hospital, Finland, and Department of Neurological Sciences, University of Helsinki, Helsinki, Finland.
Sleep Unit, Pulmonary Department, Helsinki University Central Hospital, Finland.
J Clin Sleep Med. 2014 Oct 15;10(10):1075-82. doi: 10.5664/jcsm.4104.
The Oxford Sleep Resistance Test (OSLER) is a behavioral test that measures a subject's ability to maintain wakefulness and assesses daytime vigilance. The multiple unprepared reaction time (MURT) test measures a subject's reaction time in response to a series of visual or audible stimuli.
We recruited 34 healthy controls in order to determine the normative data for MURT. Then we evaluated modifications in OSLER and MURT values in 192 patients who were referred for suspicion of sleep apnea. We performed OSLER (three 40-min sessions) and MURT (two 10-min sessions) tests at baseline. Of 173 treated OSA patients, 29 professional drivers were retested within six months of treatment.
MURT values above 250 ms can be considered abnormal. The OSLER error index (the number of all errors divided by the duration of the session in hours) correlated statistically significantly with sleep latency, MURT time, and ESS. Treatment improved OSLER sleep latency from 33 min 4 s to 36 min 48 s, OSLER error index from 66/h to 26/h, and MURT time from 278 ms to 224 ms; these differences were statistically significant.
OSLER and MURT tests are practical and reliable tools for measuring improvement in vigilance due to sleep apnea therapy in professional drivers.
牛津睡眠抵抗测试（OSLER）是一项行为测试，用于测量受试者保持清醒的能力并评估日间警觉性。多重无准备反应时间（MURT）测试测量受试者对一系列视觉或听觉刺激的反应时间。
我们招募了34名健康对照者以确定MURT的规范数据。然后，我们评估了192名因疑似睡眠呼吸暂停而前来就诊的患者的OSLER和MURT值的变化。我们在基线时进行了OSLER（三个40分钟的时段）和MURT（两个10分钟的时段）测试。在173名接受治疗的阻塞性睡眠呼吸暂停（OSA）患者中，29名职业司机在治疗后六个月内接受了重新测试。
MURT值高于250毫秒可被视为异常。OSLER错误指数（所有错误的数量除以时段持续时间（小时））与睡眠潜伏期、MURT时间和爱泼沃斯思睡量表（ESS）在统计学上显著相关。治疗使OSLER睡眠潜伏期从33分4秒改善至36分48秒，OSLER错误指数从66/小时降至26/小时，MURT时间从278毫秒降至224毫秒；这些差异具有统计学意义。
OSLER和MURT测试是用于测量职业司机因睡眠呼吸暂停治疗而导致的警觉性改善的实用且可靠的工具。
