Department of Neurology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Institute of Endocrinology and Metabolism, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Neural Regen Res. 2012 Dec 25;7(36):2874-81. doi: 10.3969/j.issn.1673-5374.2012.36.004.
Genistein is one of several isoflavones that has a structure similar to 17β-estradiol, has a strong antioxidant effect, and a high affinity to estrogen receptors. At 15 weeks after ovariectomy, the expression of Bcl-2 in the hippocampus of rats decreased and Bax expression increased, with an obvious upregulation of apoptosis. However, intraperitoneal injection of genistein or 17β-estradiol for 15 consecutive weeks from the second day after operation upregulated Bcl-2 protein expression, downregulated Bax protein expression, and attenuated hippocampal neuron apoptosis. Our experimental findings indicate that long-term intervention with genistein can lead to a decrease in apoptosis in hippocampal neurons following ovariectomy, upregulate the expression of Bcl-2, and downregulate the expression of Bax. In addition, genistein and 17β-estradiol play equal anti-apoptotic and neuroprotective roles.
染料木黄酮是与 17β-雌二醇结构相似的几种异黄酮之一，具有很强的抗氧化作用和高雌激素受体亲和力。去卵巢术后 15 周，大鼠海马 Bcl-2 表达减少，Bax 表达增加，细胞凋亡明显上调。然而，术后第二天连续 15 周腹腔内注射染料木黄酮或 17β-雌二醇可上调 Bcl-2 蛋白表达，下调 Bax 蛋白表达，减轻海马神经元凋亡。我们的实验结果表明，长期干预染料木黄酮可减少去卵巢后海马神经元凋亡，上调 Bcl-2 表达，下调 Bax 表达。此外，染料木黄酮和 17β-雌二醇发挥同等的抗凋亡和神经保护作用。
