de Camargo Caio Cavassan, Tasca Karen Ingrid, Mendes Monica Banwart, Miot Hélio Amante, de Souza Lenice do Rosário
Department of Tropical Diseases and Diagnostic Imaging, Botucatu Medical School, Universidade Estadual Paulista - UNESP, Botucatu, São Paulo, Brazil.
Department of Dermatology and Radiology, Botucatu Medical School, Universidade Estadual Paulista - UNESP, Botucatu, São Paulo, Brazil.
Open AIDS J. 2014 Sep 30;8:25-30. doi: 10.2174/1874613601408010025. eCollection 2014.
Infection with human papilloma virus (HPV) is the most common sexually transmitted disease in the world. Among the 630 million new cases of HPV that occur each year, 30 million develop anogenital warts. Although subclinical infection with HPV is the most common cause, genital warts are also associated with immunosuppression caused by HIV. In view of the high prevalence of HPV/HIV co-infection particularly among men who have sex with men, the objectives of this study were to determine the prevalence of anogenital warts in men with HIV/AIDS and to identify associated factors.
A cross-sectional study was conducted on 159 men with HIV/AIDS consecutively selected at a referral service in Botucatu, São Paulo, Brazil, in which the association between sociodemographic, behavioral and clinical variables and the presence of anogenital warts was evaluated. After hierarchical analysis of the data, variables presenting a p value ≤ 0.2 were entered into an unconditional multivariate logistic regression model.
Forty-nine (31%) of the HIV-positive patients had anogenital warts. The mean age was 44.6 ± 9.6 years. The main factors associated with the presence of anogenital warts were irregular antiretroviral treatment and genital herpes(HSV).
The present study demonstrate that anogenital warts occur in almost one-third of the male population infected with HIV and factors associated with a higher risk of being diagnosed with anogenital warts were irregular cART use and co-infection with HSV, other variables could not be associated.
人乳头瘤病毒（HPV）感染是全球最常见的性传播疾病。在每年新增的6.3亿例HPV病例中，有3000万例发展为肛门生殖器疣。虽然HPV亚临床感染是最常见的病因，但生殖器疣也与HIV引起的免疫抑制有关。鉴于HPV/HIV合并感染的高流行率，尤其是在男男性行为者中，本研究的目的是确定HIV/AIDS男性中肛门生殖器疣的患病率，并确定相关因素。
对巴西圣保罗州博图卡图一家转诊服务机构连续选取的159例HIV/AIDS男性进行了一项横断面研究，评估了社会人口统计学、行为和临床变量与肛门生殖器疣的存在之间的关联。在对数据进行分层分析后，将p值≤0.2的变量纳入无条件多变量逻辑回归模型。
49例（31%）HIV阳性患者患有肛门生殖器疣。平均年龄为44.6±9.6岁。与肛门生殖器疣存在相关的主要因素是抗逆转录病毒治疗不规律和生殖器疱疹（HSV）。
本研究表明，近三分之一感染HIV的男性患有肛门生殖器疣，与被诊断为肛门生殖器疣风险较高相关的因素是抗逆转录病毒治疗不规律和HSV合并感染，其他变量无关联。
