Middelkoop Teije C, Korswagen Hendrik C
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
WormBook. 2014 Oct 15:1-23. doi: 10.1895/wormbook.1.173.1.
During the first stage of larval development, the Q neuroblasts and their descendants migrate to well-defined positions along the anteroposterior body axis, where they differentiate into sensory neurons and interneurons. The two Q neuroblasts are initially present at similar positions on the left and right lateral side, but this symmetry is broken when the Q neuroblast on the left side (QL) polarizes towards the posterior and the Q neuroblast on the right side (QR) towards the anterior. This left-right asymmetry is maintained when the descendants of the two Q neuroblasts migrate to their final positions in the posterior and anterior. The mechanisms that establish this asymmetry and control the migration of the Q descendants along the anteroposterior axis are surprisingly complex and include interplay between Wnt signaling pathways, homeotic genes, and the basic cell migration and polarity machinery. Here, we will give an overview of what is currently known about the mechanisms that mediate and control the development and migration of the Q neuroblasts and their descendants.
在幼虫发育的第一阶段，Q神经母细胞及其后代沿着前后体轴迁移到明确的位置，在那里它们分化为感觉神经元和中间神经元。两个Q神经母细胞最初位于左右两侧的相似位置，但当左侧的Q神经母细胞（QL）向后极化而右侧的Q神经母细胞（QR）向前极化时，这种对称性就被打破了。当两个Q神经母细胞的后代迁移到前后部的最终位置时，这种左右不对称性得以维持。建立这种不对称性并控制Q后代沿前后轴迁移的机制出奇地复杂，包括Wnt信号通路、同源异型基因以及基本的细胞迁移和极性机制之间的相互作用。在这里，我们将概述目前已知的介导和控制Q神经母细胞及其后代发育和迁移的机制。
