• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DPY-14 角质层胶原蛋白调节左右不对称的神经元迁移。

The DPY-14 cuticle collagen regulates left-right asymmetric neuronal migration in .

作者信息

Lundquist Erik

机构信息

Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States.

出版信息

MicroPubl Biol. 2024 Aug 26;2024. doi: 10.17912/micropub.biology.001302. eCollection 2024.

DOI:10.17912/micropub.biology.001302
PMID:39258272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384304/
Abstract

Nervous systems of bilaterally-symmetric animals display left-right asymmetries in development. In , the Q neuroblasts display left-right asymmetry of migration, with QR on the right migrating anteriorly and QL on the left migrating posteriorly. Previous worked showed that a group of transmembrane receptor molecules including UNC-40 /DCC and PTP-3 /LAR control direction of initial Q migration. However, no classical secreted paracrine growth factor has been identified. Previous work showed that molecules in the extracellular matrix are involved, including UNC-52 /Perlecan and the cuticle collagens DPY-17 and SQT-3 . This report shows that the cuticle collagen DPY-14 is also involved, and genetically acts with DPY-17 and SQT-3 , possibly in a collagen trimer. DPY-14 might be a component of an inherent left-right chirality in the extracellular matrix that directs left-right asymmetric Q neuroblast migration.

摘要

两侧对称动物的神经系统在发育过程中表现出左右不对称性。在[具体情境未提及]中，Q神经母细胞在迁移过程中表现出左右不对称性，右侧的QR向前迁移，左侧的QL向后迁移。先前的研究表明，包括UNC-40 /DCC和PTP-3 /LAR在内的一组跨膜受体分子控制着Q细胞初始迁移的方向。然而，尚未鉴定出经典的分泌型旁分泌生长因子。先前的研究表明，细胞外基质中的分子也参与其中，包括UNC-52 /基底膜聚糖以及表皮胶原蛋白DPY-17和SQT-3。本报告表明，表皮胶原蛋白DPY-14也参与其中，并且可能在胶原蛋白三聚体中与DPY-17和SQT-3发生遗传相互作用。DPY-14可能是细胞外基质中固有左右手性的一个组成部分，该左右手性指导左右不对称的Q神经母细胞迁移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9c/11384304/617e18c46daa/25789430-2024-micropub.biology.001302.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9c/11384304/617e18c46daa/25789430-2024-micropub.biology.001302.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9c/11384304/617e18c46daa/25789430-2024-micropub.biology.001302.jpg

相似文献

1
The DPY-14 cuticle collagen regulates left-right asymmetric neuronal migration in .DPY-14 角质层胶原蛋白调节左右不对称的神经元迁移。
MicroPubl Biol. 2024 Aug 26;2024. doi: 10.17912/micropub.biology.001302. eCollection 2024.
2
The Collagens DPY-17 and SQT-3 Direct Anterior-Posterior Migration of the Q Neuroblasts in .胶原蛋白DPY-17和SQT-3直接引导Q神经母细胞在……中的前后迁移。 （原文句末不完整）
J Dev Biol. 2021 Feb 19;9(1):7. doi: 10.3390/jdb9010007.
3
The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.脂肪样钙黏蛋白 CDH-4 在后-前神经母细胞迁移中发挥非细胞自主作用。
Dev Biol. 2014 Aug 15;392(2):141-52. doi: 10.1016/j.ydbio.2014.06.009. Epub 2014 Jun 19.
4
Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.跨膜蛋白 UNC-40/DCC、PTP-3/LAR 和 MIG-21 控制线虫的前后神经母细胞迁移，并具有左右功能不对称性。
Genetics. 2012 Dec;192(4):1373-88. doi: 10.1534/genetics.112.145706. Epub 2012 Oct 10.
5
SDN-1/Syndecan Acts in Parallel to the Transmembrane Molecule MIG-13 to Promote Anterior Neuroblast Migration.SDN-1/多配体聚糖与跨膜分子MIG-13协同作用促进前神经母细胞迁移。
G3 (Bethesda). 2015 May 28;5(8):1567-74. doi: 10.1534/g3.115.018770.
6
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.线虫中UNC-40/DCC、UNC-73/Trio和DPY-19蛋白在神经母细胞迁移中建立左右不对称性。
Development. 2000 Nov;127(21):4655-68. doi: 10.1242/dev.127.21.4655.
7
Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts.部分重叠的导向途径使 UNC-40/DCC 的活性沿着极性神经母细胞的前后轴集中。
Development. 2019 Sep 25;146(18):dev180059. doi: 10.1242/dev.180059.
8
The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.胶原蛋白SQT-3的C末端在线虫胶原蛋白组装中具有复杂且重要的功能。
Genetics. 2006 Apr;172(4):2253-67. doi: 10.1534/genetics.105.053637. Epub 2006 Feb 1.
9
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans.EGL-20/Wnt和MAB-5/Hox依次发挥作用以抑制秀丽隐杆线虫中神经母细胞的向前迁移。
PLoS One. 2016 Feb 10;11(2):e0148658. doi: 10.1371/journal.pone.0148658. eCollection 2016.
10
The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.蛋白前体转化酶 BLI-4 促进了秀丽隐杆线虫表皮组装前的胶原蛋白分泌。
PLoS Genet. 2023 Sep 18;19(9):e1010944. doi: 10.1371/journal.pgen.1010944. eCollection 2023 Sep.

引用本文的文献

1
Consensus furin cleavage sites in the cuticular collagens DPY-17 and SQT-3 are required for Q neuroblast left-right asymmetric migration in .表皮胶原蛋白DPY-17和SQT-3中的共有弗林蛋白酶切割位点是Q神经母细胞在左右不对称迁移中所必需的。
MicroPubl Biol. 2025 Mar 4;2025. doi: 10.17912/micropub.biology.001526. eCollection 2025.

本文引用的文献

1
Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration.秀丽隐杆线虫 ETR-1/CELF 对肌肉细胞转录组有广泛的影响，包括调节翻译和神经母细胞迁移的基因。
BMC Genomics. 2022 Jan 6;23(1):13. doi: 10.1186/s12864-021-08217-6.
2
The Collagens DPY-17 and SQT-3 Direct Anterior-Posterior Migration of the Q Neuroblasts in .胶原蛋白DPY-17和SQT-3直接引导Q神经母细胞在……中的前后迁移。 （原文句末不完整）
J Dev Biol. 2021 Feb 19;9(1):7. doi: 10.3390/jdb9010007.
3
Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts.
部分重叠的导向途径使 UNC-40/DCC 的活性沿着极性神经母细胞的前后轴集中。
Development. 2019 Sep 25;146(18):dev180059. doi: 10.1242/dev.180059.
4
An Aneuploidy-Free and Structurally Defined Balancer Chromosome Toolkit for Caenorhabditis elegans.一种无非整倍体和结构定义的秀丽隐杆线虫平衡器染色体工具包。
Cell Rep. 2018 Jan 2;22(1):232-241. doi: 10.1016/j.celrep.2017.12.024.
5
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans.EGL-20/Wnt和MAB-5/Hox依次发挥作用以抑制秀丽隐杆线虫中神经母细胞的向前迁移。
PLoS One. 2016 Feb 10;11(2):e0148658. doi: 10.1371/journal.pone.0148658. eCollection 2016.
6
DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.DPY-17与MUA-3相互作用维持秀丽隐杆线虫中类似结缔组织的组织完整性：马凡综合征的一个模型
G3 (Bethesda). 2015 Apr 27;5(7):1371-8. doi: 10.1534/g3.115.018465.
7
Development and migration of the C. elegans Q neuroblasts and their descendants.秀丽隐杆线虫Q神经母细胞及其后代的发育与迁移。
WormBook. 2014 Oct 15:1-23. doi: 10.1895/wormbook.1.173.1.
8
The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.脂肪样钙黏蛋白 CDH-4 在后-前神经母细胞迁移中发挥非细胞自主作用。
Dev Biol. 2014 Aug 15;392(2):141-52. doi: 10.1016/j.ydbio.2014.06.009. Epub 2014 Jun 19.
9
Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.跨膜蛋白 UNC-40/DCC、PTP-3/LAR 和 MIG-21 控制线虫的前后神经母细胞迁移，并具有左右功能不对称性。
Genetics. 2012 Dec;192(4):1373-88. doi: 10.1534/genetics.112.145706. Epub 2012 Oct 10.
10
The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.富含血栓反应蛋白重复序列的蛋白 MIG-21 控制线虫迁移神经母细胞中左右不对称的 Wnt 信号反应。
Dev Biol. 2012 Jan 15;361(2):338-48. doi: 10.1016/j.ydbio.2011.10.029. Epub 2011 Oct 29.