[高剂量甲氨蝶呤药效学效应的潜在标志物——同型半胱氨酸]
[Potential marker of the pharmacodynamic effect of high doses of methotrexate--homocysteine].
作者信息
Strizhevskaya A M, Senzhapova E R, Dzamraev A Z, Baykova V N
出版信息
Patol Fiziol Eksp Ter. 2014 Apr-Jun(2):40-4.
High-dose methotrexate blocks the metabolic pathways of conversion of homocysteine to methionine. As a result, homocysteine (hcy) accumulates in the blood. The aim of this study was to determine the relationship between changes in concentrations of hcy, mtx, and other criteria of toxicity in the key hours of therapeutic drug monitoring of mtx, as well as identifying the possibility of using hcy as a marker of toxicity and effectiveness of high-dose mtx therapy. The study includes data on 246 children with osteosarcoma of different localisation.
大剂量甲氨蝶呤会阻断同型半胱氨酸转化为蛋氨酸的代谢途径。因此，同型半胱氨酸（hcy）会在血液中蓄积。本研究的目的是确定在甲氨蝶呤治疗药物监测的关键时间点，hcy浓度变化、甲氨蝶呤（mtx）浓度变化与其他毒性标准之间的关系，以及确定将hcy用作大剂量甲氨蝶呤治疗毒性和有效性标志物的可能性。该研究纳入了246例不同部位骨肉瘤患儿的数据。
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