高剂量甲氨蝶呤治疗患者血清甲氨蝶呤的微生物学测定法（作者译）
[Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].
作者信息
Krisch K, Kotz D, Mehta B M
出版信息
Wien Klin Wochenschr. 1977 Jul 15;89(14):479-81.
PMID:268729
Abstract
Microbiological assay according to Burchenal (modified by Mehta) is used for the determination of the serum methotrexate (MTX) level. Fifty cycles of high-dose MTX therapy were monitored in 11 patients with osteogenic sarcoma. The results showed close correlation with the clinical course of the therapy. The serum level of MTX was elevated in patients with symptoms of toxicity.
摘要
采用根据Burchenal法（由Mehta改良）进行的微生物学测定来测定血清甲氨蝶呤（MTX）水平。对11例骨肉瘤患者的50个高剂量MTX治疗周期进行了监测。结果显示与治疗的临床过程密切相关。出现毒性症状的患者血清MTX水平升高。
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