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高剂量甲氨蝶呤治疗患者血清甲氨蝶呤的微生物学测定法（作者译）

[Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].

作者信息

Krisch K, Kotz D, Mehta B M

出版信息

Wien Klin Wochenschr. 1977 Jul 15;89(14):479-81.

PMID:268729
Abstract

Microbiological assay according to Burchenal (modified by Mehta) is used for the determination of the serum methotrexate (MTX) level. Fifty cycles of high-dose MTX therapy were monitored in 11 patients with osteogenic sarcoma. The results showed close correlation with the clinical course of the therapy. The serum level of MTX was elevated in patients with symptoms of toxicity.

摘要

采用根据Burchenal法（由Mehta改良）进行的微生物学测定来测定血清甲氨蝶呤（MTX）水平。对11例骨肉瘤患者的50个高剂量MTX治疗周期进行了监测。结果显示与治疗的临床过程密切相关。出现毒性症状的患者血清MTX水平升高。

相似文献

1
[Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].高剂量甲氨蝶呤治疗患者血清甲氨蝶呤的微生物学测定法（作者译）
Wien Klin Wochenschr. 1977 Jul 15;89(14):479-81.
2
[The influence of liver and renal functions on the changes in serum methotrexate (MTX) level in high-dose MTX therapy].[肝肾功能对大剂量甲氨蝶呤（MTX）治疗中血清MTX水平变化的影响]
Gan To Kagaku Ryoho. 1990 Dec;17(12):2375-9.
3
[Clinical observations on the use of high-dose methotrexate treatment in osteogenic sarcoma (author's transl)].
Wien Klin Wochenschr. 1977 Jul 15;89(14):474-9.
4
No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma.甲氨蝶呤血清水平与肢体骨肉瘤术前治疗组织学反应之间无相关性。
Anticancer Drugs. 2006 Apr;17(4):411-5. doi: 10.1097/01.cad.0000203379.14738.d9.
5
[Compatibility and toxicity of methotrexate in the treatment of bone tumors].
Arzneimittelforschung. 1987 Apr;37(4):456-60.
6
[A device for rapid elevation of plasma methotrexate (MTX) concentration and its maintenance in high-dose MTX therapy].[一种用于在大剂量甲氨蝶呤治疗中快速提高血浆甲氨蝶呤（MTX）浓度并维持其浓度的装置]
Gan To Kagaku Ryoho. 1996 Apr;23(5):595-9.
7
Methotrexate levels and outcome in osteosarcoma.骨肉瘤中甲氨蝶呤的水平与预后
Pediatr Blood Cancer. 2005 Jun 15;44(7):638-42. doi: 10.1002/pbc.20314.
8
[H-MTX-CF treatment and osteogenic sarcoma (author's transl)].[高剂量甲氨蝶呤-亚叶酸钙治疗与骨肉瘤（作者译）]
Hokkaido Igaku Zasshi. 1981 Mar;56(2):235.
9
Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma.骨肉瘤甲氨蝶呤化疗中基于药代动力学监测的剂量递增
Anticancer Res. 1995 Mar-Apr;15(2):489-94.
10
[Neo-adjuvant therapy in childhood osteogenic sarcoma: a pilot study of selective postoperative chemotherapy based on response to preoperative high-dose methotrexate].儿童骨肉瘤的新辅助治疗：基于术前大剂量甲氨蝶呤反应的选择性术后化疗的初步研究
Gan To Kagaku Ryoho. 1986 May;13(5):1837-45.

引用本文的文献

1
[Multidrug chemotherapy of osteogenic sarcoma (author's transl)].骨肉瘤的多药化疗（作者译）
Blut. 1979 Oct;39(4):293-300. doi: 10.1007/BF01013224.