基于柱状芳烃的三元药物传递系统，具有光控抗癌药物释放。
A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
机构信息
State Key Laboratory of Chemical Engineering, Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China.
出版信息
Small. 2015 Feb 25;11(8):919-25. doi: 10.1002/smll.201402236. Epub 2014 Oct 15.
A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py-Cbl), a water-soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy-poly(ethylene glycol)114 -block-poly(L -lysine hydrochloride)200. This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.
构建了一种新型的三元药物传递系统（DDS），该系统使用光降解抗癌前药（Py-Cbl）、水溶性杯芳烃超分子容器（WP6）和两亲性嵌段共聚物甲氧基聚（乙二醇）114 - 聚（L - 赖氨酸盐酸盐）200。该 DDS 成功解决了三个重要问题：提高抗癌前药的水溶性；抗癌药物的控制释放；药物释放的准确和定量测量。
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