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儿童颈椎复发性动脉瘤样骨囊肿采用强力霉素注射治疗。

Recurrent aneurysmal bone cyst of the cervical spine in childhood treated with doxycycline injection.

作者信息

Doyle Anthony, Field Antony, Graydon Andrew

机构信息

Radiology with Anatomy, University of Auckland, Park Rd, Grafton, Auckland, 1023, New Zealand,

出版信息

Skeletal Radiol. 2015 Apr;44(4):609-12. doi: 10.1007/s00256-014-2027-y. Epub 2014 Oct 16.

DOI:10.1007/s00256-014-2027-y
PMID:25319562
Abstract

A 12-year-old female was treated surgically for an aneurysmal bone cyst of the cervical spine involving the C2 and C3 vertebrae. The patient underwent surgery twice and further surgery was assessed as unfeasible. Treatment by intraosseous injection of doxycycline was uncomplicated and has resulted in resolution of the multifocal recurrent disease.

摘要

一名12岁女性因颈椎骨囊肿累及C2和C3椎体接受了手术治疗。该患者接受了两次手术,进一步手术被评估为不可行。通过骨内注射强力霉素进行治疗没有并发症,并且已使多灶性复发性疾病得到缓解。

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本文引用的文献

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Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma.多西环素“超说明书使用”在一项针对胶质瘤的I期临床试验中诱导治疗性转基因表达的有效性和临床前安全性概况。
Hum Gene Ther Clin Dev. 2013 Sep;24(3):116-26. doi: 10.1089/humc.2013.139.
2
Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report.经皮多西环素治疗动脉瘤样骨囊肿低复发率:初步报告。
Clin Orthop Relat Res. 2013 Aug;471(8):2675-83. doi: 10.1007/s11999-013-3043-2. Epub 2013 May 14.
3
Surgical management of giant multilevel aneurysmal bone cyst of cervical spine in a 10-year-old boy: case report with review of literature.
脊柱动脉瘤样骨囊肿的多学科管理:单中心经验
Interv Neuroradiol. 2019 Oct;25(5):564-569. doi: 10.1177/1591019919848130. Epub 2019 May 14.
4
Aneurysmal bone cyst treated with percutaneous doxycycline: is a single treatment sufficient?经皮注射强力霉素治疗动脉瘤样骨囊肿:单次治疗是否足够?
Skeletal Radiol. 2019 May;48(5):765-771. doi: 10.1007/s00256-019-03188-y. Epub 2019 Feb 26.
5
Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine.经皮白蛋白/强力霉素注射与开放手术治疗活动脊柱动脉瘤样骨囊肿。
Eur Spine J. 2019 Jun;28(6):1529-1536. doi: 10.1007/s00586-018-5836-1. Epub 2018 Nov 23.
6
Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts.载多西环素磷酸钙骨水泥的特性:对骨巨细胞瘤治疗的影响。
J Mater Sci Mater Med. 2018 Jul 10;29(7):109. doi: 10.1007/s10856-018-6117-6.
7
Expert's comment concerning Grand Rounds case entitled "Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization" by S. Rajasekaran et al. (Eur Spine J; 2016: DOI 10.1007/s00586-016-4518-0).专家对S. Rajasekaran等人发表的题为《采用新型前路重建与稳定技术治疗C2椎体动脉瘤样骨囊肿》(《欧洲脊柱杂志》;2016年:DOI 10.1007/s00586-016-4518-0)的大查房病例的评论。
Eur Spine J. 2019 Feb;28(2):279-283. doi: 10.1007/s00586-018-5608-y. Epub 2018 Apr 23.
10岁男孩颈椎巨大多级动脉瘤样骨囊肿的手术治疗:病例报告并文献复习
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J Bone Joint Surg Am. 2011 Aug 17;93(16):1534-43. doi: 10.2106/JBJS.J.01430.
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Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3.强力霉素通过一种涉及 MMP-3 的双重机制发挥神经保护作用,防止黑质多巴胺能变性。
Neurotox Res. 2009 Nov;16(4):361-71. doi: 10.1007/s12640-009-9078-1. Epub 2009 Jul 7.
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Am J Pathol. 2004 Nov;165(5):1773-80. doi: 10.1016/S0002-9440(10)63432-3.
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AJNR Am J Neuroradiol. 2004 Jun-Jul;25(6):1116-20.