Woon Jason T K, Hoon Damien, Graydon Andrew, Flint Mike, Doyle Anthony J
Anatomy and Medical Imaging, University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand.
Department of Radiology, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand.
Skeletal Radiol. 2019 May;48(5):765-771. doi: 10.1007/s00256-019-03188-y. Epub 2019 Feb 26.
The purpose of this case series is to report on the effectiveness of a single percutaneous injection of doxycycline as a primary treatment for aneurysmal bone cyst (ABC).
A retrospective cohort study was conducted on seven patients diagnosed with ABC at various anatomical sites, with the intention to treat by a single percutaneous injection of doxycycline. Mean patient age was 14 years.
Signs of treatment response were seen in six of seven patients after one injection. Three of the seven received a second treatment, despite signs of response. Another had expansion of the lesion after treatment, requiring excision. In total, three patients had a single injection of doxycycline as their sole treatment and another three showed signs of response after a single injection.
A single percutaneous injection of doxycycline should be considered a viable primary treatment option for ABC.
本病例系列的目的是报告单次经皮注射强力霉素作为动脉瘤样骨囊肿（ABC）主要治疗方法的有效性。
对7例在不同解剖部位诊断为ABC的患者进行回顾性队列研究，旨在通过单次经皮注射强力霉素进行治疗。患者平均年龄为14岁。
7例患者中有6例在注射一次后出现治疗反应迹象。7例中有3例尽管有反应迹象仍接受了第二次治疗。另一例患者治疗后病变扩大，需要切除。总共有3例患者仅接受了单次强力霉素注射作为唯一治疗，另外3例在单次注射后出现反应迹象。
单次经皮注射强力霉素应被视为ABC可行的主要治疗选择。
