Ekici F, Tekbas G, Hattapoğlu S, Yaramış A, Önder H, Bilici A
Department of Radiology, School of Medicine, Dicle University, Radyoloji AD, 21280, Diyarbakir, Turkey.
Department of Pediatric Neurology, School of Medicine, Dicle University, 21280, Diyarbakir, Turkey.
Clin Neuroradiol. 2016 Jun;26(2):215-20. doi: 10.1007/s00062-014-0351-1. Epub 2014 Oct 16.
Our aim in this study was to analyze the findings of brain magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of children with vitamin B12 deficiency.
This study included 14 cases. The findings of brain MRI and MRS in all cases were investigated. Four patients had been followed up and mean follow-up time 71.8 (59-85) day.
Eight patients of the cases (57 %) had at least one abnormal MRI finding. The most commonly found MRI findings were thinning of the corpus callosum and brain atrophy, respectively. The mean ratio of NAA/Cr and Cho/Cr were measured in MRS, with values of 1.31 ± 0.17 and 1.04 ± 0.27, respectively. In two of three patients with abnormal MRI studies at presentation, subsequent MRI showed improvement while one patient remained unchanged. An increase in the ratios of metabolites were found in one case with control MRS. There was no lactate peak.
Brain MRI was abnormal in more than half of the cases of children with vitamin B12 deficiency. Our radiologic findings similar with literature. There was no identifiable lactate peak. B12 deficiency could be the cause of the thinning of the corpus callosum and brain atrophy in the children that were given a brain MRI.
本研究的目的是分析维生素B12缺乏儿童的脑磁共振成像（MRI）和磁共振波谱（MRS）检查结果。
本研究纳入14例患儿。对所有病例的脑MRI和MRS检查结果进行分析。4例患者进行了随访，平均随访时间为71.8（59 - 85）天。
8例患儿（57%）至少有一项MRI异常表现。最常见的MRI表现分别是胼胝体变薄和脑萎缩。在MRS中测量了NAA/Cr和Cho/Cr的平均比值，分别为1.31±0.17和1.04±0.27。在初次MRI检查异常的3例患者中，2例随后的MRI显示有所改善，1例无变化。在1例进行对照MRS检查的患者中发现代谢物比值升高。未发现乳酸峰。
超过半数的维生素B12缺乏儿童脑MRI检查异常。我们的影像学检查结果与文献报道相似。未发现可识别的乳酸峰。维生素B12缺乏可能是接受脑MRI检查的儿童胼胝体变薄和脑萎缩的原因。
