Cantelmo N L, Quist W C, Lo Gerfo F W
Harvard Surgical Service, New England Deaconess Hospital, Boston, Massachusetts.
J Cardiovasc Surg (Torino). 1989 Nov-Dec;30(6):910-5.
The purpose of this investigation was to compare and contrast the occurrence and progression of anastomotic intimal hyperplasia in two commonly used prosthetic arterial grafts. Twenty paired carotid artery interposition grafts of Dacron and PTFE (polytetrafluoroethylene) were implanted in a canine model. The grafts were electively removed at intervals from one week to seven months or at the time of thrombosis. Areas of hyperplastic growth were determined at each anastomosis using a quantitative histologic technique. The number of grafts quantitatively evaluated was 16 Dacron and 12 PTFE, excluding all thrombosed grafts. In both materials, hyperplasia occurred to a significantly greater degree at the distal or downstream anastomosis as compared with the proximal or upstream anastomosis (Dacron P less than 0.001, PTFE P less than 0.05). Quantitative and qualitative evaluation of these two commonly used but different arterial grafts did not demonstrate a significant difference in the occurrence of anastomotic hyperplasia.
本研究的目的是比较和对比两种常用人工血管移植物中吻合口内膜增生的发生情况和进展过程。将20对涤纶和聚四氟乙烯（PTFE）颈动脉搭桥移植物植入犬模型。在1周龄至7个月龄的不同时间点或血栓形成时选择性取出移植物。使用定量组织学技术确定每个吻合口处增生生长的面积。排除所有血栓形成的移植物后，定量评估的涤纶移植物有16个，聚四氟乙烯移植物有12个。在两种材料中，与近端或上游吻合口相比，远端或下游吻合口处增生的程度明显更高（涤纶P＜0.001，聚四氟乙烯P＜0.05）。对这两种常用但不同的动脉移植物进行的定量和定性评估未显示吻合口增生的发生率有显著差异。
