de Souza Fabrício T A, Kummer Arthur, Silva Maiza L V, Amaral Tânia M P, Abdo Evandro N, Abreu Mauro H N G, Silva Tarcília A, Teixeira Antônio L
Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Neuroimmunomodulation. 2015;22(4):250-5. doi: 10.1159/000367714. Epub 2014 Oct 15.
Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated.
This study investigated whether there is any association between salivary biomarkers and personality traits in BMS patients.
It was a cross-sectional, controlled study that evaluated 30 individuals with BMS and 32 controls. All subjects were assessed with a structured psychiatric interview (Mini International Neuropsychiatric Interview) and the Big Five inventory. Salivary levels of brain-derived neurotrophic factor (BDNF), neural growth factor, tumor necrosis factor-α, interleukin (IL)-6, IL-10 and cortisol were determined.
We found that BMS patients exhibited more traits of neuroticism and lower openness than controls. Openness showed a moderate and negative correlation with cortisol, BDNF and IL-6.
Personality traits are associated with salivary biomarkers in BMS.
灼口综合征（BMS）是一种慢性疾病，定义为口腔黏膜有烧灼感且无病理检查结果。其病理生理学在很大程度上尚不清楚，但精神障碍和人格特质与之有关。
本研究调查灼口综合征患者唾液生物标志物与人格特质之间是否存在关联。
这是一项横断面对照研究，评估了30例灼口综合征患者和32例对照者。所有受试者均通过结构化精神科访谈（迷你国际神经精神访谈）和大五人格量表进行评估。测定唾液中脑源性神经营养因子（BDNF）、神经生长因子、肿瘤坏死因子-α、白细胞介素（IL）-6、IL-10和皮质醇的水平。
我们发现，灼口综合征患者比对照者表现出更多的神经质特质，且开放性更低。开放性与皮质醇、BDNF和IL-6呈中度负相关。
灼口综合征患者的人格特质与唾液生物标志物有关。
