奥美拉唑继发的肉芽肿性肾小管间质性肾炎
Granulomatous tubulointerstitial nephritis secondary to omeprazole.
作者信息
Nadri Quaid, Althaf Mohammed Mahdi
机构信息
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
出版信息
BMJ Case Rep. 2014 Oct 16;2014:bcr2014203842. doi: 10.1136/bcr-2014-203842.
Abstract
Drug-induced interstitial nephritis is a common cause of acute kidney injury indicated by elevated serum creatinine. We report a case of omeprazole-induced acute granulomatous interstitial nephritis (GIN). Our patient developed acute GIN secondary to omeprazole ingestion requiring haemodialysis. Treatment with steroids and withdrawal of omperazole was successful allowing the patient to discontinue haemodialysis in 3 months. She remains dialysis free with chronic kidney disease stage IV, reflected by a serum creatine of 191 μmol/L and estimated glomerular filtration rate of 23 mL/min/1.73 m(2) at 5 years on follow-up.
摘要
药物性间质性肾炎是急性肾损伤的常见原因，表现为血清肌酐升高。我们报告一例奥美拉唑所致急性肉芽肿性间质性肾炎（GIN）。我们的患者因服用奥美拉唑继发急性GIN，需要进行血液透析。使用类固醇治疗并停用奥美拉唑取得成功，患者在3个月后停止血液透析。随访5年时，她仍未进行透析，处于慢性肾脏病IV期，血清肌酐为191μmol/L，估计肾小球滤过率为23mL/min/1.73m²。
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