DNA 折纸纳米孔：发展、挑战与展望。

DNA origami nanopores: developments, challenges and perspectives.

机构信息

Cavendish Laboratory, Cambridge University, J J Thomson Avenue, Cambridge, CB3 0HE, UK.

出版信息

Nanoscale. 2014 Nov 6;6(23):14121-32. doi: 10.1039/c4nr04094e.

Abstract

DNA nanotechnology has enabled the construction of DNA origami nanopores; synthetic nanopores that present improved capabilities for the area of single molecule detection. Their extraordinary versatility makes them a new and powerful tool in nanobiotechnology for a wide range of important applications beyond molecular sensing. In this review, we briefly present the recent developments in this emerging field of research. We discuss the current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores. Finally, we anticipate novel avenues for future research and highlight a range of exciting ideas and applications that could be explored in the near future.

摘要

DNA 纳米技术使 DNA 折纸纳米孔的构建成为可能；这些合成纳米孔在单分子检测领域具有改进的性能。它们的非凡多功能性使它们成为纳米生物技术领域的一个新的强大工具，可用于广泛的重要应用，超越了分子传感。在这篇综述中，我们简要介绍了这一新兴研究领域的最新进展。我们讨论了当前的挑战和可能的解决方案，这些解决方案将增强 DNA 折纸纳米孔的传感能力。最后，我们预计未来研究的新途径，并强调一系列令人兴奋的想法和应用，这些想法和应用在不久的将来可能会得到探索。