Ponzin D, Mancini C, Toffano G, Bruni A, Doria G
Fidia Neurobiological Research Laboratories, Abano Terme, Italy.
Immunopharmacology. 1989 Nov-Dec;18(3):167-76. doi: 10.1016/0162-3109(89)90014-3.
The action of phosphatidylserine on the immune response has been examined in mice after the intravenous administration of phospholipid or exposing cultured splenocytes to the action of phosphatidylserine vesicles. Phosphatidylserine (5-25 mg/kg) reduces the T-dependent and the T-independent antibody production. This effect is observed when the phospholipid is injected before (4 h) but not after (24 h) the immunization. The decreased influence of phosphatidylserine injected 24 h before the immunization indicates the reversibility of the action of phospholipid. The effect on the immune system may in part reflect a direct interaction with lymphocytes, since phosphatidylserine (12-60 microM) decreases the production of T-cell growth factors (mainly interleukin-2) elicited by mitogens in cultured spleen cells and reduces the expression of growth factor receptors in the same cells activated by mitogens. In addition, the activity of T-helper cells is found to be reduced in mice receiving the injection of phosphatidylserine. By contrast, the antigen processing and presentation by macrophages is not affected. The data suggest that the intravenous injection of phosphatidylserine vesicles in mice is followed by a transient decrease of lymphocyte activity.
在给小鼠静脉注射磷脂或使培养的脾细胞暴露于磷脂酰丝氨酸囊泡的作用后，已对磷脂酰丝氨酸对免疫反应的作用进行了研究。磷脂酰丝氨酸（5 - 25毫克/千克）可降低T细胞依赖性和T细胞非依赖性抗体的产生。当在免疫前（4小时）而非免疫后（24小时）注射磷脂时可观察到这种效应。免疫前24小时注射磷脂酰丝氨酸的影响减弱表明磷脂作用的可逆性。对免疫系统的影响可能部分反映了与淋巴细胞的直接相互作用，因为磷脂酰丝氨酸（12 - 60微摩尔）可降低培养的脾细胞中由有丝分裂原引发的T细胞生长因子（主要是白细胞介素-2）的产生，并降低由有丝分裂原激活的相同细胞中生长因子受体的表达。此外，在接受磷脂酰丝氨酸注射的小鼠中发现辅助性T细胞的活性降低。相比之下，巨噬细胞的抗原加工和呈递不受影响。数据表明，给小鼠静脉注射磷脂酰丝氨酸囊泡后，淋巴细胞活性会出现短暂下降。
