Jin Cong, Jiang Hong, Liang Mifang, Han Ying, Gu Wen, Zhang Fushun, Zhu Hua, Wu Wei, Chen Ting, Li Chuan, Zhang Weilun, Zhang Quanfu, Qu Jing, Wei Qiang, Qin Chuan, Li Dexin
Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
J Infect Dis. 2015 Mar 15;211(6):915-25. doi: 10.1093/infdis/jiu564. Epub 2014 Oct 17.
SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible to SFTSV infection, but the infection in nonhuman primates has not been investigated. This study is the first to report that, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases and myocardial enzymes in blood. Viremia, virus-specific immunoglobulin M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all infected macaques. Levels of the cytokines interferon γ, eotaxin, tumor necrosis factor α, and macrophage inflammatory protein 1β were significantly elevated in the blood. Minor pathological lesions were observed in the liver and kidney during the late stages of infection. Overall, SFTSV infection in rhesus macaques resembled mild SFTS in humans.
发热伴血小板减少综合征病毒（SFTSV）是一种高致病性布尼亚病毒，可引发严重发热伴血小板减少综合征（SFTS），这是一种在中国出现的传染病。据报道，实验室小鼠易感染SFTSV，但尚未对非人灵长类动物的感染情况进行研究。本研究首次报道，在恒河猴中，SFTSV不会引起严重症状或死亡，但会导致发热、血小板减少、白细胞减少以及血液中转氨酶和心肌酶水平升高。在所有感染的猕猴中均检测到病毒血症、病毒特异性免疫球蛋白M和免疫球蛋白G抗体以及中和抗体。血液中细胞因子γ干扰素、嗜酸性粒细胞趋化因子、肿瘤坏死因子α和巨噬细胞炎性蛋白1β的水平显著升高。在感染后期，肝脏和肾脏出现轻微病理病变。总体而言，恒河猴感染SFTSV的情况类似于人类的轻度SFTS。
