Göymen Abdullah, Özdurak İbrahim, Özkaplan Şükran Esra, Şimsek Yavuz, Avcı Fazıl, Akpak Yaşam Kemal
a Department of Obstetrics and Gynecology , Faculty of Medicine, Sanko University , Gaziantep , Turkey.
b Department of Obstetrics and Gynecology , Faculty of Medicine, Kirikkale University , Kirikkale , Turkey.
J Matern Fetal Neonatal Med. 2018 May;31(9):1204-1208. doi: 10.1080/14767058.2017.1312328. Epub 2017 Apr 12.
The aim of study was to determine the helicobacter pylori (HP) seropositivity and oxidative parameters in serum and saliva of pregnant women with poor oral hygiene and hyperemesis gravidarum (HG).
A case-control study was conducted involving 50 pregnant women in their first trimester of pregnancy. Twenty-five subjects had a diagnosis of HG, and remaining 25 were healthy pregnant women who served as control subjects were included. The groups were adjusted for age, parity and gestational week. All patients were subjected to the measurement of total oxidant status (TOS) and total antioxidant status in serum and saliva. Also HP seropositivity was investigated.
Serum TAS and TOS values were similar, although oxidative burden in saliva of women with HG were significantly higher than controls. HP seropositivity was found to be 24% in women with HG and 4% of controls.
Our results suggest that significantly increased oxidative burden and slightly decreased antioxidative capacity of saliva may be involved in the pathogenesis of HG and this condition may be the result of HP infection which was found to be significantly more common in women with poor oral hygiene and HG.
本研究旨在确定口腔卫生差及妊娠剧吐（HG）孕妇血清和唾液中的幽门螺杆菌（HP）血清阳性率及氧化参数。
进行了一项病例对照研究，纳入50名妊娠早期孕妇。其中25名受试者被诊断为HG，其余25名健康孕妇作为对照。根据年龄、产次和孕周对两组进行匹配。所有患者均接受血清和唾液中总氧化剂状态（TOS）和总抗氧化剂状态的测定。同时调查HP血清阳性情况。
血清总抗氧化剂状态（TAS）和TOS值相似，尽管HG女性唾液中的氧化负担显著高于对照组。HG女性的HP血清阳性率为24%，对照组为4%。
我们的结果表明，唾液中氧化负担显著增加和抗氧化能力略有下降可能参与了HG的发病机制，这种情况可能是HP感染的结果，在口腔卫生差和HG的女性中，HP感染明显更常见。
