Suppr超能文献

多巴胺拮抗作用会降低付出体力努力的意愿,但不会降低付出认知努力的意愿:两种啮齿动物成本/收益决策任务的比较。

Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks.

作者信息

Hosking Jay G, Floresco Stan B, Winstanley Catharine A

机构信息

Department of Psychology, University of British Columbia, Vancouver, BC, Canada.

出版信息

Neuropsychopharmacology. 2015 Mar;40(4):1005-15. doi: 10.1038/npp.2014.285. Epub 2014 Oct 20.

Abstract

Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every severe mental illness. Animal models of such cost/benefit decision making overwhelmingly implicate mesolimbic dopamine in our willingness to exert effort for a larger reward. Until recently, however, animal models have invariably manipulated the degree of physical effort, whereas human studies of effort have primarily relied on cognitive costs. Dopamine's relationship to cognitive effort has not been directly examined, nor has the relationship between individuals' willingness to expend mental versus physical effort. It is therefore unclear whether willingness to work hard in one domain corresponds to willingness in the other. Here we utilize a rat cognitive effort task (rCET), wherein animals can choose to allocate greater visuospatial attention for a greater reward, and a previously established physical effort-discounting task (EDT) to examine dopaminergic and noradrenergic contributions to effort. The dopamine antagonists eticlopride and SCH23390 each decreased willingness to exert physical effort on the EDT; these drugs had no effect on willingness to exert mental effort for the rCET. Preference for the high effort option correlated across the two tasks, although this effect was transient. These results suggest that dopamine is only minimally involved in cost/benefit decision making with cognitive effort costs. The constructs of mental and physical effort may therefore comprise overlapping, but distinct, circuitry, and therapeutic interventions that prove efficacious in one effort domain may not be beneficial in another.

摘要

成功的决策往往需要权衡给定选项的成本与其相关收益,而这种能力在几乎每一种严重精神疾病中似乎都受到了干扰。在这种成本/收益决策的动物模型中,中脑边缘多巴胺在很大程度上影响着我们为获得更大奖励而付出努力的意愿。然而,直到最近,动物模型一直都是在操纵体力付出的程度,而关于努力的人体研究主要依赖于认知成本。多巴胺与认知努力之间的关系尚未得到直接研究,个体在付出脑力与体力努力方面的意愿之间的关系也未得到研究。因此,尚不清楚在一个领域努力工作的意愿是否与另一个领域的意愿相对应。在这里,我们利用大鼠认知努力任务(rCET),即动物可以选择为了更大的奖励而分配更多的视觉空间注意力,以及一个先前建立的体力努力折扣任务(EDT),来研究多巴胺能和去甲肾上腺素能对努力的贡献。多巴胺拮抗剂依托必利和SCH23390均降低了在EDT上付出体力努力的意愿;这些药物对在rCET上付出脑力努力的意愿没有影响。在这两个任务中,对高努力选项的偏好存在相关性,尽管这种影响是短暂的。这些结果表明,多巴胺在涉及认知努力成本的成本/收益决策中只起到了最小的作用。因此,脑力和体力努力的结构可能包含重叠但不同的神经回路,在一个努力领域被证明有效的治疗干预措施在另一个领域可能并无益处。

相似文献

4
Δ-Tetrahydrocannabinol decreases willingness to exert cognitive effort in male rats.
J Psychiatry Neurosci. 2017 Mar;42(2):131-138. doi: 10.1503/jpn.150363.
5
Dopamine restores cognitive motivation in Parkinson's disease.
Brain. 2019 Mar 1;142(3):719-732. doi: 10.1093/brain/awy341.
7
Sensitivity to cognitive effort mediates psychostimulant effects on a novel rodent cost/benefit decision-making task.
Neuropsychopharmacology. 2012 Jul;37(8):1825-37. doi: 10.1038/npp.2012.30. Epub 2012 Mar 28.
8
Dopaminergic modulation of risk-based decision making.
Neuropsychopharmacology. 2009 Feb;34(3):681-97. doi: 10.1038/npp.2008.121. Epub 2008 Jul 30.
10
Acute stress induces selective alterations in cost/benefit decision-making.
Neuropsychopharmacology. 2012 Sep;37(10):2194-209. doi: 10.1038/npp.2012.69. Epub 2012 May 9.

引用本文的文献

1
Effects of physical effort on temporal processing.
J Exp Psychol Hum Percept Perform. 2025 Jul 24. doi: 10.1037/xhp0001366.
2
Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning.
Schizophr Res Cogn. 2024 Aug 24;38:100325. doi: 10.1016/j.scog.2024.100325. eCollection 2024 Dec.
3
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats.
Psychopharmacology (Berl). 2024 Oct;241(10):2033-2044. doi: 10.1007/s00213-024-06615-8. Epub 2024 Jun 6.
5
Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.
Neuropsychopharmacology. 2024 Jul;49(8):1309-1317. doi: 10.1038/s41386-024-01826-1. Epub 2024 Mar 1.
6
Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats.
Psychopharmacology (Berl). 2024 May;241(5):947-962. doi: 10.1007/s00213-023-06521-5. Epub 2024 Jan 3.
7
Dissociable neural after-effects of cognitive and physical effort expenditure during reward evaluation.
Cogn Affect Behav Neurosci. 2023 Dec;23(6):1500-1512. doi: 10.3758/s13415-023-01131-2. Epub 2023 Oct 11.
8
Amphetamines Improve the Motivation to Invest Effort in Attention-Deficit/Hyperactivity Disorder.
J Neurosci. 2023 Oct 11;43(41):6898-6908. doi: 10.1523/JNEUROSCI.0982-23.2023. Epub 2023 Sep 4.
9
What can challenging reproductive contexts tell us about the rat's maternal behavior?
Front Behav Neurosci. 2023 Jul 14;17:1239681. doi: 10.3389/fnbeh.2023.1239681. eCollection 2023.

本文引用的文献

1
Toward an understanding of decision making in severe mental illness.
J Neuropsychiatry Clin Neurosci. 2014 Summer;26(3):196-213. doi: 10.1176/appi.neuropsych.12110268.
3
Dopamine prediction error responses integrate subjective value from different reward dimensions.
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2343-8. doi: 10.1073/pnas.1321596111. Epub 2014 Jan 22.
5
Beyond dopamine: the noradrenergic system and mental effort.
Behav Brain Sci. 2013 Dec;36(6):698-9; discussion 707-26. doi: 10.1017/S0140525X13001106.
6
Control of basal ganglia output by direct and indirect pathway projection neurons.
J Neurosci. 2013 Nov 20;33(47):18531-9. doi: 10.1523/JNEUROSCI.1278-13.2013.
8
Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking.
Neuropsychopharmacology. 2012 Oct;37(11):2456-66. doi: 10.1038/npp.2012.104. Epub 2012 Jun 27.
9
Dopaminergic mechanisms of individual differences in human effort-based decision-making.
J Neurosci. 2012 May 2;32(18):6170-6. doi: 10.1523/JNEUROSCI.6459-11.2012.
10
Distinct roles for direct and indirect pathway striatal neurons in reinforcement.
Nat Neurosci. 2012 Jun;15(6):816-8. doi: 10.1038/nn.3100.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验