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烟草习惯、人乳头瘤病毒（HPV）感染、p53基因多态性/突变与口腔鳞状细胞癌风险之间的关系。

Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma.

作者信息

Chakrobarty Bidyut, Roy Jay Gopal, Majumdar Sumit, Uppala Divya

机构信息

Department of Oral Pathology, Burdwan Dental College, Burdwan, India.

Department of Oral Pathology, Dr. R. Ahmed Dental College, Kolkata, West Bengal, India.

出版信息

J Oral Maxillofac Pathol. 2014 May;18(2):211-6. doi: 10.4103/0973-029X.140752.

DOI:10.4103/0973-029X.140752
PMID:25328301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4196289/
Abstract

The prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.

摘要

在多个国家，口腔鳞状细胞癌（OSCC）的患病率在过去几十年中显著上升，人乳头瘤病毒（HPV）被认为是潜在病因之一。这表明HPV在致癌作用的早期阶段发挥作用，但对于恶性状态的维持和进展并非必需。p53是一种肿瘤抑制基因，可检查细胞并促进细胞凋亡和修复，它可能因突变和病毒相互作用而失活，从而导致癌症，而具有特定p53多态性变体的个体更容易发生HPV诱导的致癌作用。本研究旨在检测有吸烟习惯的口腔癌患者活检样本中的p53多态性/突变以及HPV DNA，并进行相关性分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408a/4196289/75e91dec6d6c/JOMFP-18-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408a/4196289/a4b58447a0d9/JOMFP-18-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408a/4196289/75e91dec6d6c/JOMFP-18-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408a/4196289/a4b58447a0d9/JOMFP-18-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408a/4196289/75e91dec6d6c/JOMFP-18-211-g002.jpg

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