Tanaka Kenichiro, Wada-Isoe Kenji, Yamamoto Mikie, Tagashira Shugo, Tajiri Yuki, Nakashita Satoko, Nakashima Kenji
Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Brain Behav. 2014 Sep;4(5):643-9. doi: 10.1002/brb3.247. Epub 2014 Jul 6.
Fatigue is a common nonmotor symptom of Parkinson's disease (PD). Although the causes of fatigue were estimated in the previous reports, fatigue is not fully understood. To determine the frequency of and factors related to fatigue in patients with PD, we carried out clinical assessments in our university hospital.
We used the Japanese version of the Parkinson Fatigue Scale (J-PFS). The J-PFS was administered to 110 patients with PD, and a cutoff point of 3.3 was used for the diagnosis of fatigue. Subsequently, demographic characteristics, clinical features, and medications utilized were evaluated to elucidate the factors related to fatigue. In particular, we focused on the relationship between fatigue and gait disorder assessed via the portable gait rhythmogram.
The frequency of fatigue in patients with PD was 52.7%. Univariate analysis revealed that factors significantly associated with fatigue were many motor symptoms and nonmotor symptoms. In addition, multivariate analysis revealed that gait disorder and constipation were independent factors related to fatigue. Furthermore, short-step walking and bradykinesia in gait disorder had especially a relationship with fatigue.
More than half of our patients were judged having fatigue. Several factors, including motor and nonmotor symptoms, might be related to fatigue in patients with PD.
疲劳是帕金森病（PD）常见的非运动症状。尽管既往报告对疲劳的病因进行了评估，但疲劳仍未被完全理解。为了确定PD患者疲劳的发生率及相关因素，我们在我校医院进行了临床评估。
我们使用帕金森疲劳量表日文版（J-PFS）。对110例PD患者进行J-PFS评估，以3.3作为疲劳诊断的临界值。随后，评估患者的人口统计学特征、临床特征及所用药物，以阐明与疲劳相关的因素。特别地，我们重点关注通过便携式步态节律图评估的疲劳与步态障碍之间的关系。
PD患者疲劳的发生率为52.7%。单因素分析显示，与疲劳显著相关的因素包括许多运动症状和非运动症状。此外，多因素分析显示，步态障碍和便秘是与疲劳相关的独立因素。此外，步态障碍中的短步幅行走和运动迟缓与疲劳尤其相关。
我们的患者中超过一半被判定有疲劳。包括运动和非运动症状在内的多种因素可能与PD患者的疲劳有关。
