帕金森病疲劳的可能临床预测因素：作为国际非运动症状量表验证项目的一部分，对 135 名患者的研究。
The possible clinical predictors of fatigue in Parkinson's disease: a study of 135 patients as part of international nonmotor scale validation project.
机构信息
National Parkinson Foundation Centre of Excellence, King's College Hospital, King's College London, Denmark Hill Campus, 9th Floor, Ruskin Wing, > London SE5 9RS, UK.
出版信息
Parkinsons Dis. 2011;2011:125271. doi: 10.4061/2011/125271. Epub 2011 Dec 5.
Abstract
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.
摘要
疲劳是帕金森病中一种常见但尚未被充分了解和研究的非运动症状。尽管疲劳已被认为会显著影响与健康相关的生活质量，但它仍未被充分认识，也未得到经验性治疗。在本文中，通过经过验证的视觉模拟量表和帕金森病非运动症状量表（PDNMSS）测量的疲劳患病率与其他运动和非运动合并症相关。在一系列不同疾病阶段的患者队列中，疲劳的发生与更晚期的帕金森病以及抑郁、焦虑和睡眠障碍密切相关，暗示着潜在的共同基础。
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