National Parkinson Foundation Centre of Excellence, King's College Hospital, King's College London, Denmark Hill Campus, 9th Floor, Ruskin Wing, > London SE5 9RS, UK.
Parkinsons Dis. 2011;2011:125271. doi: 10.4061/2011/125271. Epub 2011 Dec 5.
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson's disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson's disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.
疲劳是帕金森病中一种常见但尚未被充分了解和研究的非运动症状。尽管疲劳已被认为会显著影响与健康相关的生活质量，但它仍未被充分认识，也未得到经验性治疗。在本文中，通过经过验证的视觉模拟量表和帕金森病非运动症状量表（PDNMSS）测量的疲劳患病率与其他运动和非运动合并症相关。在一系列不同疾病阶段的患者队列中，疲劳的发生与更晚期的帕金森病以及抑郁、焦虑和睡眠障碍密切相关，暗示着潜在的共同基础。
