评估产前暴露于内分泌干扰化学物质与儿童肥胖之间关联所面临的挑战及未来方向。
Challenges and future directions to evaluating the association between prenatal exposure to endocrine disrupting chemicals and childhood obesity.
作者信息
Romano Megan E, Savitz David A, Braun Joseph M
机构信息
Department of Epidemiology, Brown University, Providence, Rhode Island.
出版信息
Curr Epidemiol Rep. 2014 Jun;1(2):57-66. doi: 10.1007/s40471-014-0007-3.
Abstract
Obesity is an increasing public health threat worldwide. However, there has been insufficient research addressing the obesogenic potential of prenatal exposure to environmental endocrine disrupting chemicals, largely due to complexities in the design, analysis, and interpretation of such studies. This review describes relevant biological mechanisms, addresses current challenges for investigators, presents potential strategies for overcoming them, and identifies areas where further development is required to improve future research. Special considerations for exposure assessment, outcome heterogeneity, and complex confounding structures are described.
摘要
肥胖是全球范围内日益严重的公共卫生威胁。然而，关于产前暴露于环境内分泌干扰化学物质的致肥胖潜力的研究一直不足，这主要是由于此类研究在设计、分析和解释方面存在复杂性。本综述描述了相关的生物学机制，探讨了研究人员目前面临的挑战，提出了克服这些挑战的潜在策略，并确定了未来研究需要进一步发展以改进的领域。文中还描述了暴露评估、结果异质性和复杂混杂结构的特殊注意事项。
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