Bonner Michael Y, Arbiser Jack L
Department of Dermatology, Winship Cancer Institute, Atlanta, GA, USA.
Future Med Chem. 2014;6(12):1413-22. doi: 10.4155/fmc.14.86.
So-called antioxidants have yet to make a clinical impact on the treatment of human cancer. The reasons for this failure are several. First, many agents that are called antioxidants are truly antioxidants at a given dose, but this dose may not have been given in clinical trials. Second, many agents are not antioxidants at all. Third, not all tumors use reactive oxygen as a signaling mechanism. Finally, reactive oxygen inhibition is often insufficient to kill or regress a tumor cell by itself, but requires sequential introduction of a therapeutic agent for maximal effect. We hope to provide a framework for the logical use of these agents in cancer.
所谓的抗氧化剂尚未对人类癌症治疗产生临床影响。失败的原因有几个。首先，许多被称为抗氧化剂的药物在给定剂量下确实是抗氧化剂，但该剂量可能未在临床试验中使用。其次，许多药物根本不是抗氧化剂。第三，并非所有肿瘤都将活性氧用作信号传导机制。最后，活性氧抑制本身往往不足以杀死肿瘤细胞或使其消退，而是需要依次引入治疗药物以达到最大效果。我们希望为这些药物在癌症治疗中的合理使用提供一个框架。
