Moiseev I N
Biull Eksp Biol Med. 1989 Sep;108(9):297-9.
A corrective effect of Nicotinamide on oxidation processes in ganglion and neuroglial cells of cerebral cortex sensorimotor zone in "kindling" phenomenon was studied in the experiments on mice of C57BL line. The kindling was caused by daily injection of Corazol in a dose of 30 micrograms/kg intraperitoneally during one month. The experimental mice were introduced Corazol by the same scheme but beginning from the 4th week Nicotinamide was injected daily/5, 50, 200 mg/kg intraperitoneally/30 min before Corazol introduction. Cytophotometric investigations of enzyme activity/glytamate-, succinate-, -glycerophosphate, glucose-6-phosphate-dehydrogenase and NADH-tetrazol reductase/showed that the most optimum dose of nicotinamide stimulating the tissue oxidation in the dose of 50 mg/kg. It was also established that nicotinamide in the dose of 50 mg/kg has a definite antispasmodic effect and increases ganglion cells stability to destructive effect of epiphogenic factors.
在C57BL系小鼠实验中，研究了烟酰胺对“点燃”现象中大脑皮质感觉运动区神经节和神经胶质细胞氧化过程的纠正作用。“点燃”是通过在一个月内每天腹腔注射30微克/千克剂量的可拉佐引起的。实验小鼠按相同方案注射可拉佐，但从第4周开始，在注射可拉佐前30分钟每天腹腔注射烟酰胺/5、50、200毫克/千克。对酶活性/谷氨酸、琥珀酸、甘油磷酸、葡萄糖-6-磷酸脱氢酶和NADH-四氮唑还原酶/的细胞光度学研究表明，刺激组织氧化的烟酰胺最适宜剂量为50毫克/千克。还确定，50毫克/千克剂量的烟酰胺具有一定的解痉作用，并增加神经节细胞对致痫因素破坏作用的稳定性。
