Moiseev I N, Pcheliakov V F, Shandra A A, Makul'tin R F, Godlevskiĭ L S
Biull Eksp Biol Med. 1987 Jan;103(1):10-2.
The activity of glutamate, succinate, malate and lactate dehydrogenases in neuronal and glial hippocampal cells during corazol kindling has been cytophotometrically assessed in the experiments on (CBA X C57BL/6)F1 mice. The kindling was induced by regular intraperitoneal corazol injections in subliminal dose of 30 mg/kg. Histochemical investigations were performed 30 min, 24 hours and 30 days after the corazol injections were discontinued. The changes in the enzymatic activity revealed suggest the biphasic nature of the disturbances in energy metabolism. During the first phase (24 hours after the last injection) the enzymatic changes do not have a noticeable influence on the predominant aerobic type of oxidation. In the second phase (30 days after the last injection) lactate dehydrogenase activity significantly increases, while the activity of other enzymes under study reduces.
在（CBA×C57BL/6）F1小鼠实验中，通过细胞光度法评估了在戊四氮点燃过程中，海马神经元和神经胶质细胞中谷氨酸、琥珀酸、苹果酸和乳酸脱氢酶的活性。点燃是通过以30mg/kg的阈下剂量定期腹腔注射戊四氮诱导的。在停止注射戊四氮后30分钟、24小时和30天进行组织化学研究。所揭示的酶活性变化表明能量代谢紊乱具有双相性。在第一阶段（最后一次注射后24小时），酶的变化对主要的有氧氧化类型没有明显影响。在第二阶段（最后一次注射后30天），乳酸脱氢酶活性显著增加，而其他所研究酶的活性降低。
