Zhang Zhiguo, Zhang Wei, Li Junlong, Liu Qingfeng, Liu Tongxin, Zhang Guisheng
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, P. R. China.
J Org Chem. 2014 Nov 21;79(22):11226-33. doi: 10.1021/jo5018487. Epub 2014 Oct 31.
An alternative route has been developed for the construction of multisubstituted pyrrole derivatives from readily available, doubly activated cyclopropanes and anilines using an iron-mediated oxidation domino reaction (i.e., sequential ring-opening, cyclization, and dehydrogenation reactions). This reaction uses readily available reactants and is tolerant of a broad range of substrates, with the desired products being formed in good to excellent yields.
已经开发出一种替代路线，用于从易于获得的双活化环丙烷和苯胺出发，通过铁介导的氧化多米诺反应（即顺序开环、环化和脱氢反应）构建多取代吡咯衍生物。该反应使用易于获得的反应物，并且对多种底物具有耐受性，所需产物的产率良好至优异。
