蛋白质乙酰化与精子发生
Protein acetylation and spermatogenesis.
作者信息
Pang Aly, Rennert Om
机构信息
Laboratory of Clinical and Developmental Genomics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
出版信息
Reprod Syst Sex Disord. 2013 Jun 3;Suppl 1:5. doi: 10.4172/2161-038x.s1-005.
Spermatogenesis refers to the developmental process of male germ cell formation from the spermatogonial stem cell to mature spermatozoa. The progression of male germ cells through the different phases of development, along with changes in cellular size and morphology, involves a coordinated change in their gene expression program at both the transcript and protein levels. It is well known that the stability, biological activity and cellular localization of proteins are regulated by post-translational modifications. In this review, we provide a brief update of current knowledge about the role of protein acetylation in mammalian spermatogenesis. Based on recent findings specific examples were cited to illustrate how these modifications are involved in controlling the different events that are important to the proper development of male germ cells.
精子发生是指从精原干细胞到成熟精子的雄性生殖细胞形成的发育过程。雄性生殖细胞在不同发育阶段的进程，以及细胞大小和形态的变化，涉及转录和蛋白质水平上基因表达程序的协调变化。众所周知，蛋白质的稳定性、生物活性和细胞定位受翻译后修饰的调控。在本综述中，我们简要介绍了目前关于蛋白质乙酰化在哺乳动物精子发生中作用的知识更新。基于最近的研究结果，引用了具体例子来说明这些修饰如何参与控制对雄性生殖细胞正常发育至关重要的不同事件。
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