氯碘羟喹对后柱核功能的选择性神经毒性。

Selective neurotoxicity of clioquinol on the function of the posterior column nuclei.

作者信息

Arasaki K, Nakanishi T

机构信息

Department of Neurology, University of Tsukuba, Japan.

出版信息

Neurosci Lett. 1989 Dec 15;107(1-3):85-8. doi: 10.1016/0304-3940(89)90795-7.

DOI:10.1016/0304-3940(89)90795-7

PMID:2533335

Abstract

In the gracile nucleus of clioquinol-treated rats, the presynaptic inhibition was remarkably diminished, and the excitatory synaptic transmission was less intensely inhibited by a conditioning sural nerve volley. These changes may be the pathophysiology responsible for paresthesia and/or dysesthesia in patients with subacute optico-myelo-neuropathy (SMON).

摘要

在服用氯碘羟喹的大鼠的薄束核中，突触前抑制显著减弱，并且条件性腓肠神经冲动对兴奋性突触传递的抑制作用也减弱。这些变化可能是亚急性视神经脊髓神经病（SMON）患者感觉异常和/或感觉迟钝的病理生理学原因。