镍催化卤代烷烃和酰氯与对甲苯磺酸甲酯的还原甲基化反应。
Nickel-catalyzed reductive methylation of alkyl halides and acid chlorides with methyl p-tosylate.
机构信息
College of Chemistry and Molecular Engineering, Zhengzhou University , 100 Science Road, Zhengzhou 450001, China.
出版信息
Org Lett. 2014 Nov 7;16(21):5620-3. doi: 10.1021/ol502682q. Epub 2014 Oct 21.
PMID:25333482
Abstract
Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions.
摘要
在镍催化的还原偶联条件下，未活化的卤代烷烃和酰氯的甲基化反应导致使用甲基对甲苯磺酸酯作为甲基化试剂，高效地生成了甲基化的烷烃和酮。在目前温和且易于操作的反应条件下，观察到中等至优异的偶联产率以及优异的官能团耐受性。
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