Hamaguchi H, Hashimoto T, Mori K, Tayama M
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
Brain Dev. 1989;11(6):399-406. doi: 10.1016/s0387-7604(89)80024-5.
Polysomnographic recordings were obtained for 10 Down syndrome (DS) children (6 males and 4 females, 9 months to 7 years old) and 16 age-matched normal controls. The present study was conducted to study the sleep characteristics of DS patients of this age group. The percentage of each sleep stage, rapid eye movements (REMs)/min, time intervals between REMs(I)/min, times of awakening in the middle of sleep, body movements (BMs) and twitch movements (TMs) were studied. I/min was divided into three frequencies: I less than 1 sec, l less than or equal to I less than 2 sec and I greater than or equal to 2 sec. Two of the 10 patients showed an increase in the percentage of REM sleep. In the group aged 1 to 5 years old, the REMs/min and I/min (I less than 1 sec) values were higher than those in normal controls (p less than 0.05). Many times of awakening in the middle of sleep (greater than or equal to 5 times and/or greater than or equal to 60 min) were observed in 4 cases. The frequency of BMs in total sleep was higher than that in controls (p less than 0.01). Five of the 10 cases showed an abnormal pattern as to the frequency of BMs during each sleep stage. The frequency of TMs was less than that in controls (total sleep and stage 1, p less than 0.05; stage REM, p less than 0.01). Seven of 9 cases showed an abnormal pattern as to the frequency of TMs during each sleep stage.(ABSTRACT TRUNCATED AT 250 WORDS)
对10名唐氏综合征（DS）儿童（6名男性和4名女性，年龄在9个月至7岁之间）和16名年龄匹配的正常对照者进行了多导睡眠图记录。本研究旨在探讨该年龄组DS患者的睡眠特征。研究了每个睡眠阶段的百分比、快速眼动（REM）次数/分钟、REM之间的时间间隔（I）/分钟、睡眠中觉醒次数、身体运动（BM）和抽搐运动（TM）。I/分钟分为三个频率：I小于1秒、1小于或等于I小于2秒和I大于或等于2秒。10名患者中有2名显示REM睡眠百分比增加。在1至5岁的年龄组中，REM次数/分钟和I/分钟（I小于1秒）的值高于正常对照组（p小于0.05）。4例患者观察到多次睡眠中觉醒（大于或等于5次和/或大于或等于60分钟）。总睡眠中BM的频率高于对照组（p小于0.01）。10例中有5例在每个睡眠阶段的BM频率呈现异常模式。TM的频率低于对照组（总睡眠和第1阶段，p小于0.05；REM阶段，p小于0.01）。9例中有7例在每个睡眠阶段的TM频率呈现异常模式。（摘要截断于250字）
