Baek Tae-Hwa, Lim Nam-Kyoo, Kim Min-Ju, Lee Joungwon, Ryu Seungho, Chang Yoosoo, Choi Yuni, Park Hyun-Young
From the 1Division of Cardiovascular and Rare Disease, Center for Biomedical Science, Korea National Institute of Health, Cheongwon, Republic of Korea; 2Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; and 3Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Menopause. 2015 May;22(5):542-8. doi: 10.1097/GME.0000000000000353.
Recent studies have demonstrated that earlier menarche is associated with increased risks of prediabetes and diabetes in white women; however, the associations have not been fully explored in Asian populations. We investigated the associations between age at menarche and prediabetes and/or diabetes in Korean middle-aged women.
This was a cross-sectional study of 2,039 premenopausal and postmenopausal women aged 44 to 56 years who visited the health promotion center for medical checkups. Participants were divided into three groups based on age at menarche: early (<13 y), average (13-16 y), and late (>16 y).
The mean (SD) age at menarche was 14.6 (1.6) years. Of 2,039 women, 820 and 85 women had prediabetes (impaired fasting glucose and/or 5.7%-6.4% glycated hemoglobin) and diabetes, respectively. On logistic regression analysis, earlier menarche was significantly associated with prediabetes (odds ratio [OR], 1.80; 95% CI, 1.24-2.61; P = 0.002), diabetes (OR, 2.43; 95% CI, 1.04-5.69; P = 0.04), and dysglycemia (OR, 1.85; 95% CI, 1.28-2.66; P = 0.001), after adjusting for a number of confounding factors, compared with average age at menarche. On linear regression analysis, earlier age at menarche was significantly associated with increased fasting insulin, homeostatic model assessment for insulin resistance, homeostatic model assessment for β-cell function, body mass index, and waist circumference.
Age at menarche is inversely associated with various forms of dysglycemia. A history of earlier menarche may be helpful in predicting prediabetes and subsequent diabetes in Korean women.
近期研究表明，初潮较早与白人女性前驱糖尿病和糖尿病风险增加有关；然而，在亚洲人群中这些关联尚未得到充分研究。我们调查了韩国中年女性初潮年龄与前驱糖尿病和/或糖尿病之间的关联。
这是一项横断面研究，研究对象为2039名年龄在44至56岁之间前往健康促进中心进行体检的绝经前和绝经后女性。参与者根据初潮年龄分为三组：早发组（<13岁）、平均组（13 - 16岁）和晚发组（>16岁）。
初潮的平均（标准差）年龄为14.6（1.6）岁。在2039名女性中，分别有820名和85名患有前驱糖尿病（空腹血糖受损和/或糖化血红蛋白5.7% - 6.4%）和糖尿病。在逻辑回归分析中，与初潮平均年龄相比，在调整了多个混杂因素后，初潮较早与前驱糖尿病（比值比[OR]，1.80；95%置信区间，1.24 - 2.61；P = 0.002）、糖尿病（OR，2.43；95%置信区间，1.04 - 5.69；P = 0.04）和血糖异常（OR，1.85；95%置信区间，1.28 - 2.66；P = 0.001）显著相关。在线性回归分析中，初潮年龄较早与空腹胰岛素升高、胰岛素抵抗稳态模型评估、β细胞功能稳态模型评估、体重指数和腰围显著相关。
初潮年龄与各种形式的血糖异常呈负相关。初潮较早的病史可能有助于预测韩国女性的前驱糖尿病和随后的糖尿病。
