Pan Weiyi, Wu Chenzhou, Su Zhifei, Duan Zexi, Li Longjiang, Mi Fanglin, Li Chunjie
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Oncotarget. 2017 Aug 9;8(37):62508-62523. doi: 10.18632/oncotarget.20096. eCollection 2017 Sep 22.
Genetic polymorphisms, including single nucleotide polymorphisms (SNP) and nucleotide repeat expansions, can occur in regions that transcribe non-coding RNAs (ncRNA), such as, but not limited to, micro RNA and long non-coding RNA. An association between genetic polymorphisms of ncRNA and increasing head and neck cancer (HNC) risk has been identified by several studies. Therefore, the aim of this systematic review is to consolidate existing findings to clarify this association. Four electronic databases, such as MEDLINE, EMBASE, Chinese BioMedical Literature Database, and China National Knowledge Infrastructure, were utilised. Inclusion of studies and data extraction were accomplished in duplicate. A total of 42 eligible studies were included, involving 28,527 cases and 37,151 controls. Meta-analysis, sensitivity analysis and publication bias detection were performed. Among the eligible studies, 102 SNPs were investigated, and 21 of them were considered eligible for meta-analysis. Our analysis revealed that HOTAIR rs920778, uc003opf.1 rs11752942, and miR-196a2 rs11614913 were related to HNC susceptibility, while let-7 rs10877887, miR-124-1rs531564, and miR-608 rs4919510 were considered as protective factors. In conclusion, our results showed the extreme importance of an up-to-date comprehensive meta-analysis encompassing the most recent findings to obtain a relevant and reliable framework to understand the relationship between ncRNA SNPs and HNC susceptibility.
基因多态性，包括单核苷酸多态性（SNP）和核苷酸重复扩增，可发生在转录非编码RNA（ncRNA）的区域，如但不限于微小RNA和长链非编码RNA。多项研究已确定ncRNA的基因多态性与头颈癌（HNC）风险增加之间存在关联。因此，本系统评价的目的是整合现有研究结果以阐明这种关联。我们使用了四个电子数据库，如MEDLINE、EMBASE、中国生物医学文献数据库和中国知网。研究的纳入和数据提取均重复进行。共纳入42项符合条件的研究，涉及28527例病例和37151例对照。进行了荟萃分析、敏感性分析和发表偏倚检测。在符合条件的研究中，共调查了102个SNP，其中21个被认为符合荟萃分析的条件。我们的分析表明，HOTAIR rs920778、uc003opf.1 rs11752942和miR-196a2 rs11614913与HNC易感性相关，而let-7 rs10877887、miR-124-1rs531564和miR-608 rs4919510被认为是保护因素。总之，我们的结果表明，进行包含最新研究结果的最新综合荟萃分析对于获得一个相关且可靠的框架以理解ncRNA SNP与HNC易感性之间的关系极为重要。
