Radiant Research Services Pvt Ltd, Bangalore, India.
Nizam Institute of Pharmacy, Nalgonda, India.
Bioimpacts. 2014;4(3):113-6. doi: 10.15171/bi.2014.003. Epub 2014 Sep 21.
Hyperglycemia is a serious health problem prevailing in diabetes patients. Treatment for hyperglycemia by various oral anti-hyperglycemic drugs have associated with side effects, hence there is growing awareness towards the use of herbal products due to their efficacy, minimal side effects and relatively low costs. This study is designed to evaluate anti-hyperglycemic activity of Caralluma umbellata Haw, which is used as a traditional medicinal plant all over India through in vitro studies.
Methanolic, aqueous and hydro methanolic extracts of Caralluma umbellata were prepared and studied for their anti hyperglycemic activity. The extracts were evaluated for glucose uptake in L6 myotubes in vitro. In addition, the inhibitory activity against alpha amylase and pancreatic lipase was also measured.
The methanolic extract (MCU) was found to have significant glucose uptake. Further, MCU was also found to have promising role in inhibiting alpha amylase and pancreatic lipase.
The results of present study shows Caralluma umbellata has potential antidiabetic property, thus providing a further scope for study in animal model and understanding the mechanism of action.
高血糖是糖尿病患者普遍存在的严重健康问题。各种口服降血糖药物治疗高血糖与副作用相关，因此由于其疗效、副作用极小且成本相对较低，人们越来越关注使用草药产品。这项研究旨在通过体外研究评估在印度各地用作传统药用植物的 Caralluma umbellata Haw 的降血糖活性。
制备并研究了 Caralluma umbellata 的甲醇、水和水甲醇提取物，以研究其降血糖活性。在体外评估了这些提取物对 L6 肌管中葡萄糖摄取的作用。此外，还测量了对α-淀粉酶和胰脂肪酶的抑制活性。
发现甲醇提取物（MCU）具有显著的葡萄糖摄取作用。此外，MCU 还在抑制α-淀粉酶和胰脂肪酶方面表现出有希望的作用。
本研究结果表明 Caralluma umbellata 具有潜在的抗糖尿病特性，因此为在动物模型中进行进一步研究和了解作用机制提供了进一步的研究范围。
