甲型肝炎病毒IA亚基因型引起的急性肝炎作为一种从印度尼西亚输入的传染病。

Acute hepatitis due to hepatitis A virus subgenotype IA as an imported infectious disease from Indonesia.

作者信息

Utsumi Takako, Yano Yoshihiko, Amin Mochamad, Lusida Maria I, Hotta Hak, Hayashi Yoshitake

机构信息

Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

Kobe J Med Sci. 2014 Oct 1;60(2):E43-7.

PMID:25339259

Abstract

A 25-year-old Japanese man was admitted with general malaise and fever, which had developed 12 days after coming back to Japan from Indonesia. Blood examination revealed elevated transaminase levels and positivity for the IgM anti-HAV antibody; therefore, he was diagnosed with acute hepatitis A. HAV-RNA was detected in his serum and phylogenetically classified as subgenotype IA. The partial genome in the VP1/P2A region was consistent with the strain recently isolated from Surabaya, which indicated that he had been infected during his stay in Indonesia. Thus, HAV vaccination is recommended before visiting HAV-endemic countries for a long period of time.

摘要

一名25岁的日本男子因全身不适和发热入院，这些症状在他从印度尼西亚返回日本12天后出现。血液检查显示转氨酶水平升高，IgM抗甲型肝炎病毒抗体呈阳性；因此，他被诊断为急性甲型肝炎。在他的血清中检测到甲型肝炎病毒RNA，并在系统发育上分类为IA亚基因型。VP1/P2A区域的部分基因组与最近从泗水分离出的毒株一致，这表明他在印度尼西亚逗留期间受到了感染。因此，建议在长期访问甲型肝炎流行国家之前接种甲型肝炎疫苗。