Department of Pediatrics, Federal Medical Centre , Katsina , Nigeria.
Neonatal Intensive Care Unit, Department of Pediatrics, University of Ilorin Teaching Hospital , Ilorin , Nigeria.
Front Pediatr. 2014 Oct 8;2:105. doi: 10.3389/fped.2014.00105. eCollection 2014.
In Nigeria, of the over 900,000 children under the age of 5 years that die every year, perinatal mortality is responsible for a little over 20%. Previous reports are largely from the southern part of the country. This is the first report of perinatal data from the northwest of Nigeria.
A case control study of perinatal deaths in the three major public hospitals in Katsina metropolis was carried out to determine the pattern of perinatal deaths in the metropolis. Data were collected over a 6 week period on maternal socio-demographic, antenatal, and delivery variables. Data were similarly obtained on neonatal profile and morbidities.
There were 143 perinatal deaths (94 stillbirths and 49 early neonatal deaths) out of 1104 live and stillbirths during the study period. The perinatal mortality rate was thus 130 per 1000 births with a stillbirth rate of 85 per 1000 births and an early neonatal mortality rate of 49 per 1000 live births. Stillbirths during the intrapartum period were twice as frequent as macerated stillbirths (2:1). Maternal factors significantly associated with perinatal deaths included chorioamnionitis, ruptured uterus, multiple gestation, medically induced delivery, prolonged labor, unbooked pregnancies, antepartum hemorrhage, and prolonged rupture of membranes. Antepartum hemorrhage was the strongest determinant of perinatal death. Significant neonatal determinants were multiple gestation, severe birth asphyxia, apnea, and necrotizing enterocolitis. Apnea was the strongest neonatal determinant. The majority (83.2%) of perinatal deaths were due to severe perinatal asphyxia (SPA) (54.5%), normally formed macerated stillbirths (20.3%), and immaturity (8.4%).
In conclusion, Perinatal Mortality in Katsina metropolis in northwest Nigeria is unacceptably high as we approach the timeline for the millennium development goals. Antepartum hemorrhage and SPA are major determinants.
在尼日利亚,每年有超过 90 万名 5 岁以下儿童死亡,围产期死亡占比略高于 20%。之前的报告主要来自该国南部。这是尼日利亚西北部首次报告围产期数据。
对卡齐纳大都市区三家公立医院的围产儿死亡进行病例对照研究,以确定大都市区围产儿死亡模式。研究期间,在 6 周内收集了产妇社会人口统计学、产前和分娩变量的数据。新生儿特征和发病率的数据也同样获得。
在研究期间,1104 例活产和死产中有 143 例围产儿死亡(94 例死产和 49 例早期新生儿死亡)。围产儿死亡率为 130/1000 例,死产率为 85/1000 例,早期新生儿死亡率为 49/1000 例活产。分娩期间的死产是胎死宫内的两倍(2:1)。与围产儿死亡显著相关的产妇因素包括绒毛膜羊膜炎、子宫破裂、多胎妊娠、医学诱导分娩、产程延长、无预约妊娠、产前出血和胎膜早破。产前出血是围产儿死亡的最强决定因素。显著的新生儿决定因素是多胎妊娠、严重出生窒息、呼吸暂停和坏死性小肠结肠炎。呼吸暂停是最强的新生儿决定因素。大多数(83.2%)围产儿死亡是由于严重围产期窒息(SPA)(54.5%)、正常形成的胎死宫内(20.3%)和不成熟(8.4%)。
总之,尼日利亚西北部卡齐纳大都市区的围产期死亡率非常高,我们接近千年发展目标的时间线。产前出血和 SPA 是主要决定因素。