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Remyelination therapy goes to trial for multiple sclerosis.

作者信息

Brugarolas Pedro, Popko Brian

机构信息

Department of Neurology, The University of Chicago, Chicago, IL.

出版信息

Neurol Neuroimmunol Neuroinflamm. 2014 Aug 21;1(2):e26. doi: 10.1212/NXI.0000000000000026. eCollection 2014 Aug.

DOI:10.1212/NXI.0000000000000026
PMID:25340076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4202671/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/4202671/4f6b39b4f9fd/NEURIMMINFL2014001974FF1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/4202671/4f6b39b4f9fd/NEURIMMINFL2014001974FF1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/4202671/4f6b39b4f9fd/NEURIMMINFL2014001974FF1.jpg

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本文引用的文献

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Randomized phase I trials of the safety/tolerability of anti-LINGO-1 monoclonal antibody BIIB033.抗 LINGO-1 单克隆抗体 BIIB033 的安全性/耐受性的随机 I 期临床试验。
Neurol Neuroimmunol Neuroinflamm. 2014 Aug 21;1(2):e18. doi: 10.1212/NXI.0000000000000018. eCollection 2014 Aug.
2
Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.微柱阵列作为多发性硬化症治疗的高通量筛选平台。
Nat Med. 2014 Aug;20(8):954-960. doi: 10.1038/nm.3618. Epub 2014 Jul 6.
3
The translational biology of remyelination: past, present, and future.
Metab Brain Dis. 2023 Mar;38(3):739-747. doi: 10.1007/s11011-022-01138-7. Epub 2023 Jan 3.
4
The Analysis of SNPs' Function in miR-21 and miR146a/b in Multiple Sclerosis and Active Lesions: An In Silico Study.多发性硬化症及活动病灶中miR-21和miR146a/b的单核苷酸多态性（SNP）功能分析：一项计算机模拟研究
Bioinform Biol Insights. 2022 Aug 4;16:11779322221116322. doi: 10.1177/11779322221116322. eCollection 2022.
5
The Current Challenges for Drug Discovery in CNS Remyelination.中枢神经系统髓鞘再形成药物研发的当前挑战。
Int J Mol Sci. 2021 Mar 12;22(6):2891. doi: 10.3390/ijms22062891.
6
Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.用小分子促进体内髓鞘再生：多发性硬化症的神经修复药理学治疗。
Sci Rep. 2017 Mar 3;7:43545. doi: 10.1038/srep43545.
7
Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes.多发性硬化症中的精准医学：炎症和反应性星形胶质细胞PET成像的未来。
Front Mol Neurosci. 2016 Sep 15;9:85. doi: 10.3389/fnmol.2016.00085. eCollection 2016.
8
Extracellular cues influencing oligodendrocyte differentiation and (re)myelination.影响少突胶质细胞分化和（再）髓鞘形成的细胞外信号
Exp Neurol. 2016 Sep;283(Pt B):512-30. doi: 10.1016/j.expneurol.2016.03.019. Epub 2016 Mar 23.
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Mol Neurobiol. 2016 Sep;53(7):4406-16. doi: 10.1007/s12035-015-9375-z. Epub 2015 Aug 5.
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Functional regeneration of the brain: white matter matters.大脑的功能再生：白质至关重要。
Neural Regen Res. 2015 Mar;10(3):355-6. doi: 10.4103/1673-5374.153675.
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Neuroimage. 2007 Jul 15;36(4):1152-8. doi: 10.1016/j.neuroimage.2007.03.073. Epub 2007 May 3.
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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.LINGO-1是Nogo-66受体/p75信号复合物的一个组成部分。
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