Quijada Pearl, Sussman Mark A
Integrated Regenerative Research Institute, Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA.
Expert Rev Cardiovasc Ther. 2014 Nov;12(11):1275-88. doi: 10.1586/14779072.2014.972941.
Despite the increasing use of stem cells for regenerative-based cardiac therapy, the optimal stem cell population(s) remains in a cloud of uncertainty. In the past decade, the field has witnessed a surge of researchers discovering stem cell populations reported to directly and/or indirectly contribute to cardiac regeneration through processes of cardiomyogenic commitment and/or release of cardioprotective paracrine factors. This review centers upon defining basic biological characteristics of stem cells used for sustaining cardiac integrity during disease and maintenance of communication between the cardiac environment and stem cells. Given the limited successes achieved so far in regenerative therapy, the future requires development of unprecedented concepts involving combinatorial approaches to create and deliver the optimal stem cell(s) that will enhance myocardial healing.
尽管干细胞在基于再生的心脏治疗中的应用日益增多，但最佳的干细胞群体仍不明朗。在过去十年中，该领域涌现出大量研究人员，他们发现了一些干细胞群体，据报道这些群体可通过心肌生成过程和/或释放心脏保护旁分泌因子直接和/或间接促进心脏再生。本综述聚焦于定义用于在疾病期间维持心脏完整性以及维持心脏环境与干细胞之间通讯的干细胞的基本生物学特性。鉴于目前再生治疗取得的成功有限，未来需要开发前所未有的概念，采用组合方法来创建和递送能够增强心肌愈合的最佳干细胞。
